| Agent Name |
p-Toluidine |
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| CAS Number |
106-49-0 |
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| Formula |
C7-H9-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-4-methylbenzene; 4-Amino-1-methylbenzene; 4-Aminotoluen [Czech]; 4-Aminotoluene; 4-Methylaniline; 4-Methylbenzenamine; 4-Toluidine; Aniline, p-methyl-; Benzenamine, 4-methyl-; C.I. 37107; C.I. Azoic Coupling Component 107; CI 37107; CI Azoic Coupling Component 107; Naphtol AS-KG; Naphtol AS-KGLL; Toluidine, p-; p-Aminotoluene; p-Methylaniline; p-Methylbenzenamine; p-Toluidin [Czech]; p-Toluidyna [Polish]; p-Tolylamine; [ChemIDplus] UN1993 |
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| Category |
Amines, Aromatic |
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| Description |
White solid with an aromatic odor. [Note: Used as a basis for many dyes.]; [NIOSH] |
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| Sources/Uses |
Intermediate used in the organic synthesis of dyes, reagents, and other chemicals; [ACGIH] |
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| Comments |
Solid form causes first degree burns on short exposure; [CHRIS] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.] Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; A potential skin sensitizer; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
2 ppm |
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| Vapor Pressure |
0.28 mm Hg |
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| Odor Threshold Low |
0.02 ppm |
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| Odor Threshold High |
3.2 ppm |
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| Lethal Concentration |
LC50 (rats) > 640 mg/m3/1h |
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| Explanatory Notes |
Odor threshold from AIHA; Flash point = 87 deg C; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Nephrotoxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 4-AMINOTOLUENE
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