Inclusion Criteria:

• Male or female 30 years and above
• Must carry a diagnosis of idiopathic Parkinson's disease (PD), without any other known or suspected cause of parkinsonism, according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria
• For early stage patients the initial diagnosis of PD must have been made within the 5 years prior to Screening with at least two or more of the following cardinal signs being present: bradykinesia, resting tremor, rigidity, and postural instability. In addition, they must not have developed motor complications from L-dopa use
• Early stage patients must be modified Hoehn & Yahr Stage 1 to 3 (inclusive)
• Must have a screening UPDRS (Part III) motor score of at least 10 Patients may be receiving amantadine, anticholinergics, COMT inhibitors and/or MAO-B inhibitor provided the dose was stable for at least 4 weeks prior to screening; dopamine agonists and/or L-dopa/carbidopa are permitted at screening but must be discontinued at least 14 days before baseline
• Good general health as determined by a thorough medical history and physical examination (including vital signs), 12-lead ECG and clinical laboratory tests
• Patients have clinical laboratory values within normal reference range or must not be clinically significantly abnormal as judged by the Investigator and approved by the Sponsor
• Patients taking prescription drug therapy or OTC medication for chronic medical conditions must be on stable doses for at least two (2) weeks prior to participation in the study and off any investigational drug for at least 60 days
• Females of childbearing potential must be using an acceptable method of contraception, have a negative urine pregnancy test at screening, and a negative urine pregnancy test on admission. Acceptable methods of contraception are oral, intrauterine, implantable, injectable contraceptives, double barrier methods or condoms impregnated with spermicide. After screening, patients using oral contraceptive methods of contraception must agree to add an additional method until 30 days following the last dose of study medication. Women on oral contraceptives must have been using them for at least one month prior to screening
• Male patients with partners of childbearing potential must use adequate contraception for 3 months after the study
• Female patients who have been surgically sterilized or have had a partial oopherectomy (i.e., one ovary intact) are eligible if they have a negative pregnancy test at screening and admission Be able to read, understand, and provide written/dated informed consent before enrolling in the study, and must be willing to comply with all study procedures;
• Patients must be willing and able to be confined to the clinical research unit as required by the protocol
• Patients must refrain from strenuous physical activity beginning 24 hours prior to screening and through the duration of the study
• Smokers may be enrolled if they have stable smoking habits

Exclusion Criteria:

• A Mini Mental State Examination (MMSE) score < 26
• History or clinical features consistent with an atypical parkinsonian syndrome
• History of surgical intervention for PD
• History of L-dopa-induced motor or non-motor complication
• History of severe allergic or anaphylactic reactions to any drug
• Clinically significant abnormal baseline ECG; QTcF > 450 msec for males, > 470 msec for females
• Recent history of severe dizziness or fainting due to postural hypotension; orthostatic blood pressure decrease defined as a drop in systolic BP of ≥ 40 mmHg and or a drop in diastolic BP of ≥ 20 mmHg following 5 minutes supine and 2 minutes standing in conjunction with symptoms.
• Evidence of clinically significant unstable allergic (except for untreated, asymptomatic, seasonal allergies at time of dosing), hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric or neurological disease
• History of cancer within 5 years of screening; except basal and squamous cell skin cancers and carcinoma in situ of the cervix
• Any condition that may affect drug absorption
• History of allergies, or known sensitivity, hypersensitivity, or adverse reaction to any drug similar to aplindore
• Pregnant or lactating females
• Recent history or current evidence of drug abuse or alcoholism; or withdrawal
• Introduction or dose change of hormone replacement therapy within 3 months