Senior Staff
Biosketch
Dr. Machado is both a senior staff physician in the Clinical Center’s Critical Care Medicine Department and the Vascular Medicine Branch of the National Heart, Lung, and Blood Institute.
A native of Brazil, he earned his medical degree at Universidade Federal do Rio Grande do Sul. He then completed an internship, residency and chief residency at University of Miami, Jackson Memorial Hospital/VA Medical Center. Next he held a fellowship in the Department of Pulmonary and Critical Care Medicine at Cleveland Clinic Foundation, followed by a clinical fellowship at NIH in the Laboratory of Chemical Biology of the National Institute of Diabetes and Digestive and Kidney Disorders in 2003-2004.
His research focuses on hemolysis associated pulmonary hypertension, HIV-associated pulmonary arterial hypertension, vascular endothelial function in pulmonary arterial hypertension and carbon monoxide biology and therapeutics.
Honors and Awards
NIH Bench-to-Bedside Research Award, 2007, 2005; Plenary presentation, American Society of Hematology meeting, Atlanta, 2005; Leadership Development Program for Academic Physicians in Pulmonary and Critical Care Medicine, American College of Chest Physicians, 2001; Certificate of Appreciation, Department of Veteran Affairs, 2000; Chief Resident Award, American College of Physicians/American Society of Internal Medicine, Florida Chapter, 1999.; Medical Service Outstanding Intern Award. University of Miami/ Jackson Memorial Hospital, 1996-1997
Selected Publications
BOOKS and BOOK CHAPTERS
Machado, RF, Mehta A, Enobronchial Electrocautery. In: Wang, K, Mehta, A and Turner, J, eds. Flexible Bronchoscopy, second edition, Malden, MA: Blackwell Science, 2004, 185-190.
Machado, RF, Dweik R, Detmer, S, Ahmad, M, Drug-Induced Pulmonary Disease. In: Crapo, J, Glassroth, J, Karlinsky, J and King, T, eds. Textbook of Pulmonary Diseases, seventh edition, Philadelphia, PA: Lippincott Williams & Wilkins, 2004, 557-577.
Machado, RF, Saad, C, Mehta A, Enobronchial Electrocautery. In: Beamis, J, Mathur, P and Mehta, A, eds. Interventional Pulmonary Medicine, New York, NY: Marcel Dekker, 2004, 167-180.
Machado RF, Gladwin, MT, Hemolytic Anemia Associated Pulmonary Hypertension, In: Pulmonary Vascular Disease. Mandel, J and Taichman, D, eds., first edition, Philadelphia, PA, Saunders Elsevier, 2006, 170-187.
JOURNAL ARTICLES
Machado, RF, Londhe-Nerkar, M, dweik, RA, Hammel, J, Janocha, A, Pyle, J, Laskowski, D, Jennings, C, Arroliga, AC, Erzurum, SC, Nitric Oxide as a Determinant of Pulmonary Arterial Pressures in Pulmonary Hypertension, Free Radical Biology and Medicine 37(7):1010-7, 2004
Hunter, CJ, Dejam, A, Blood, AB, Machado RF, Tarekegn, S, Hopper, AO, Schechter, AN, Power, GG, Gladwin, MT, Inhaled Nebulized Nitrite Is a Hypoxia-sensitive Nitric Oxide-dependent Selective Pulmonary Vasodilator, Nature Medicine 10(10): 1122-27, 2004
Machado, RF, Gladwin, MT, Chronic Sickle Cell Lung Disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension, in press British Journal of Haematology 129(4): 449-64, 2005
Dejam, A, Hunter, CJ, Pelletier, M, Hsu, L, Machado, RF, Shiva, S, Greer JJ, Bonnel, A, Lefer, D, Power, GG, Kelm, M, Gladwin, MT, Schechter, AN, Erythrocytes are the Major Intravascular Store of Nitrite in Human Blood, Blood 106 (2):734-9, 2005
Machado, RF, Martyr, S, Kato, GJ, Barst, RJ, Robinson, MR, Hunter, LA , Coles, WA, Nichols, J, Hunter, CJ, Sachdev, V, Castro, O, Gladwin, MT, Sildenafil Therapy in Patients with Sickle Cell Disease and Hemolysis Associated Pulmonary Hypertension, British Journal of Haematology 130(3):445-53, 2005
Kato, GJ, McGowan, V, Machado, RF, Little, JA, Taylor VI, JG, Morris, CR, Nichols, JS, Wang, S, Poljakovic, M, Morris Jr., SM, Gladwin, MT Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease, Blood 107(6):2279-85, 2006
Machado, RF, Anthi, A, Steinberg, MH, Bonds, D, Sachdev, V, Kato, GJ, Taveira da Silva, AM, Ballas, SK, Blackwelder, W, Xu, X, Hunter, L, Barton, B, Waclawiw, M, Castro, O, Gladwin, MT, N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA 296(3):310-8, 2006
Machado, RF, Martyr, S, Sachdev, V, Ernst, I, Hunter, LA , Coles, WA, Nichols, J, Hunter, CJ, Kato, GJ, Gladwin, MT, Severity of Pulmonary Hypertension During Vaso-occlusive Pain Crisis and Exercise in Patients with Sickle Cell Disease , British Journal of Haematology 136 (2): 319-25, 2007
Barnett, CF, Machado RF, Sildenafil in the Treatment of Pulmonary Hypertension, Vascular Health and Risk Management (4): 411-22, 2006
Sachdev, V, Machado, RF, Shizukuda, Y, Rao, Y, Sidenko, V, Ernst, I, St. Peter, M, Coles, WA, Rosing, D, Blackwelder, WC, Castro, O, Kato, GJ, Gladwin, MT, Diastolic Dysfunction Is an Independent Risk Factor for Death in Patients with Sickle Cell Disease, Journal of the American College of Cardiology 49(4): 472-9, 2007
Machado, RF, Anthi, A, Jison, ML, Taveira-DaSilva, AM, Rubin, LJ, Hunter, L, Hunter, CJ, Coles, W, Nichols, J, Avila, N, Sachdev, V, Chen, CC, Gladwin, MT, Cardiopulmonary Function in Patients with Sickle Cell Disease and Hemolysis-Associated Pulmonary Hypertension, in press American Journal of Respiratory and Critical Care Medicine 175(12): 1272-9, 2007