Biosketch

Dr. Eichacker is currently a senior investigator and head of the Critical Care Medicine Section in the Clinical Center’s Critical Care Medicine Department at the National Institutes of Health. He earned his undergraduate degree from Boston University and his medical degree from New York University. After he completed a residency and chief residency in internal medicine, he had a fellowship in Pulmonary Medicine at Bronx Municipal Hospital Center and Hospital of the Albert Einstein College of Medicine in New York. Dr. Eichacker joined the National Institutes of Health in 1986 as a CCMD fellow.

His primary research interests are the pathogenesis and treatment of septic shock, sepsis-induced lung injury related to commonly encountered types of bacteria as well as to the less-common anthrax bacterium, and anthrax-related cardiovascular injury.

Honors and Awards

Clinical Center Patient Safety Champion Award, 2007; Trans-NIH/FDA Biodefense program grant (3 years), 2005; PHS Outstanding Unit Citation Award, 2004 and 2003; NIH Clinical Center Director’s Award, 1999; Washington D.C. Area Critical Care Society Research Award, 1999; Society of Critical Care Medicine President’s Citation Award, 1998; PHS Commendation Medal, 1994; Society of Critical Care Medicine (SCCM) Award for Finest Young Investigator, 1994; Fellowship, American College of Chest Physicians, 1994; Society of Critical Care Medicine (SCCM) Award for Finest Poster Presentation, 1993.

Selected Publications

Book/Book Chapters

Eichacker PQ, Pugin J, editors. Evolving Concepts in Sepsis and Septic Shock. Norwell: Kluwer Academic Publishers; 2000.

Journal Articles

Cui X, Moayeri M, Li Y, Fitz Y, Correa-Araujo R, Gladwin M, Banks SM, Natanson C, Leppla SH, Eichacker PQ. Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol 2004; 286: R699-R709

Cui X, Parent C, Gerstenberger E, Solomon S, Fitz Y, Danner R, Banks SM, Natanson C, Eichacker PQ. Severity of sepsis alters the effects of superoxide anion inhibition in a rat model of sepsis. J Appl Physio 2004; 97: 1349-1357

Cui X, Li Y, Moayeri M, Choi GH, Subramanian GM, Li X, Haley M, Fitz Y, Feng J, Banks SM, Leppla SH, Eichacker PQ. Late treatment with protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin infused rat model of anthrax sepsis. J Infect Dis. 2005; 191: 422-434

Haley M, Parent C, Cui X, Fitz Y, Correa-Araujo R, Danner RL, Banks SM, Natanson C, Eichacker PQ. Neutrophil inhibition with L-selectin MAb improves or worsens survival dependent on route but not severity of infectious challenge in a rat E. coli sepsis model. J Appl Physiol.2005; 98: 2155-2162

Solomon S, Cui X, Gerstenberger E, Natanson C, Danner RL, Fitz Y, Banks SM, Suganuma A, Eichacker PQ. Effective dosing in rats of lipid A analogue E5564 in rats depends on timing of treatment and route of infection. J Infect Dis. 2006; 193: 634-644

Cui X, Li Y, Li X, Haley M, Moayeri M, Fitz Y, Banks SM, Leppla SH, Eichacker PQ. Sublethal doses of B. anthracis lethal toxin inhibit inflammation with LPS and E. coli challenge but have opposite effects on survival. J Infect Dis. 2006; 193: 829-840

Li X, Cui X, Li Y, Fitz Y, Hsu L, Eichacker PQ. Parthenolide has limited effects on nuclear factor-kappa beta increases and worsens survival in lipopolysaccharide challenged C57BL/6J mice. Cytokine. 2006; 33: 299-308

Eichacker PQ, Natanson C, Danner RL. Surviving sepsis – practice guidelines, marketing campaigns, and Eli Lilly. N Engl J Med. 2006; 355: 1640-1642.

Cui X, Li Y, Li X, Laird MW, Subramanian M, Moayeri M, Leppla SH, Fitz Y, Su J, Sherer K, Eichacker PQ. B. anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model. J Infect Dis 2007; 195: 572-580.

Sherer K, Li Y, Cui X, Eichacker PQ. Perspective on the roles of lethal and edema toxins in the pathogenesis of B. anthracis septic shock: Implications for therapy. Am J Respir Crit Care Med. 2007; 175: 211-221