Biosketch

Dr. Shelhamer became a senior investigator in the Clinical Center’s Critical Care Medicine Department in 1981 and has served in his present position as deputy chief since 1990. He obtained a BA from Baylor University and an MD from Baylor College of Medicine. He completed an internship and residency in internal medicine at Baylor Affiliated Hospitals in Houston, Texas. He was chief resident of medicine there as well. He came to NIH for a fellowship at the National Institute of Allergy and Infectious Diseases. Afterward, he completed a fellowship in pulmonary medicine at Johns Hopkins Hospital and returned to NIAID as a senior staff fellow.

His research interests include mechanisms of lung cellular responses to inflammation and respiratory disease in the immunosuppressed host. He directs a laboratory research program that focuses on lung inflammation.

Honors and Awards

NIH Clinical Center Director’s Award, 2006, 2002, 1996; NIH Director’s Award, 1998; Public Health Service Unit Commendation, 1991; Public Health Service Outstanding Service Medal, 1990; NIH Clinical Center Distinguished Clinical Educator Award, 1989; Public Health Service Commendation Medal, 1985

Selected Publications

BOOKS/BOOK CHAPTERS

Sneller MC and Shelhamer JH. Immunologic Non-asthmatic Diseases of the Lung. In Middleton’s Allergy, 7th Edition. Adkinson NF, Busse W, Bochner BS, Holgate ST, Simons EF, and Lemanske R eds. Elsevier. London. 2007; In press

JOURNAL ARTICLES

Han C, Demetris AJ, Liu Y, Shelhamer JH, Wu T. TGF-b activates cPLA2a-mediated PGE2/EP1 and PPAR-g/SMAD signaling pathways in human liver cancer cells: A novel mechanism for subversion of TGF-b-induced mitoinhibition. J. Biol. Chem. 2004;279:44344-44354

Pawliczak R, Logun C, Madara P, Lawrence M, Woszczek G, Ptasinska A, Kowalski ML, Wu T and Shelhamer JH. Cytosolic phospholipase A2 Group IVa but not secreted phospholipase A2, Group IIA, V or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through PPAR-g 1 and 2 in human lung cells. J. Biol. Chem. 2004;277:48551-48561

Cowan MJ, Yao X-L, Pawliczak R, Huang X-L, Logun C, Madara P, Alsaaty S, Wu T, Shelhamer JH. The role of TFIID, the initiator element and a novel 5’ TFIID binding site in the transcriptional control of the TATA-less human cytosolic phospholipase A2-a promoter. Biochim. Biophys. ACTA. 2004; 1680:145-157

Pawliczak R, Logun C, Madara P, Barb J, Suffredini A, Munson P, Danner R and Shelhamer JH. The Influence of Interferon Gamma (IFN-g) on gene expression in normal human bronchial epithelial cells: Modulation of IFN-g effects by dexamethasone. Physiological Genomics. 2005; 23:28-45

Wozczek G, Pawliczak R, Qi H-Y, Nagineni S, Alsaaty S, Logun C, Shelhamer JH. Functional characterization of human cysteinyl leukotriene 1 recptor (cysLT1R) gene structure. J. Immunol. 2005;175:5152-5159

Qi H, Shelhamer JH. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in LPS-stimulated macrophages. J. Biol. Chem. 2005; 280:38969-38975

Talwar S, Munson PJ, Barb J, Fiuza C, Cintron AP, Logun C, Tropea M, Khan S, Reda D, Shelhamer JH, Danner RL, and Suffredini AF. Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans. Physiological Genomics. 2006; 25:203-15

Cowan MJ, Coll T, Shelhamer JH. Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2-dependent through decreases in COX-2 and cPLA2 protein levels. J. Appl. Physiol. 2006;101:1127-35

Woszczek G, Chen L-Y, Nagineni S, Alsaaty S, Harry A, Logun C, Pawliczak R, Shelhamer JH. Interferon gamma (IFN-γ) induces cysteinyl leukotriene receptor 2 (CYSLTR2) expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes. J. Immunol. 2007; 178:5262-5270