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Sponsors and Collaborators: |
University of Sydney Meat & Livestock Australia National Heart Foundation |
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Information provided by: | University of Sydney |
ClinicalTrials.gov Identifier: | NCT00254215 |
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors. The study compares a conventional reduced-fat, high carbohydrate diet with 3 means of reducing glycemic load: changing the carbohydrates to low-GI choices, replacing some of the carbohydrate with protein, or combining both effects to produce the lowest glycemic load.
Condition | Intervention | Phase |
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Overweight Obesity |
Behavioral: high protein & low glycemic index diets |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | The Effect of 4 Diets Varying in Glycemic Index, Glycemic Load, Carbohydrate and Protein, on Weight, Body Composition and Cardio-Vascular Risk Factors |
Estimated Enrollment: | 120 |
Study Start Date: | March 2002 |
Estimated Study Completion Date: | October 2004 |
Conventional low fat diets produce modest wegiht loss at best and the results are not well maintained. More recently there has been interest in low glycemic index and high protien diets wiht some evidence that these produce better fat loss and improvement in cardiovascular risk factors. This trial aims to evaluate these different approaches and compare the outcomes over 12 weeks. Major outcomes are weigth loss, body composition change, blood lipids change, measures of glucose homeostasis, insulin resistance, leptin and CRP.
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
medications other than the contraceptive pill weight >150kg (weight limit of DEXA machine) vegetarian (diets included red meat) specific diets diabetes or impaired glucose tolerance pregnancy
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Australia, New South Wales | |
University of Sydney | |
Sydney, New South Wales, Australia, 2006 |
Principal Investigator: | Jennie C Brand-Miller, PhD | University of Sydney |
Study ID Numbers: | NHF G02S 0768 - Brand-Miller |
Study First Received: | November 13, 2005 |
Last Updated: | November 27, 2006 |
ClinicalTrials.gov Identifier: | NCT00254215 |
Health Authority: | Australia: Human Research Ethics Committee |
overweight obesity glycemic index |
glycemic load high protein diet blood cholesterol |
Body Weight Signs and Symptoms Obesity Weight Loss |
Nutrition Disorders Overnutrition Overweight |
Cardiovascular Diseases |