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Sponsors and Collaborators: |
National Taiwan University Hospital National Science Council, Taiwan |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00755430 |
Autism spectrum disorder (ASD) has been given a high priority for genetic and neurobiological study. There is no such information in Asian population and no study has conducted using Diffusion Spectrum Imaging (DSI) to investigate the connectivity throughout the world. Moreover, no follow-up study has been done to examine the developmental changes of structural and functional connectivity. We anticipate to establishing a cohort of 50 ASD and their siblings with complete clinical, neuropsychological, brain imaging, and genetic data for longitudinal study on ASD. Our findings will contribute to our understanding of the structural and functional dysconnectivity for ASD and whether dysconnectivity can be an endophenotype for ASD and used as a biomarker for early diagnosis of ASD.
Condition |
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Autism Spectrum Disorder |
Study Type: | Observational |
Study Design: | Cohort |
Official Title: | Structural and Functional Connectivity in Autism Spectrum Disorders by Using Diffusion Spectrum Imaging and Functional Magnetic Resonance Imaging Studies |
The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments.
Estimated Enrollment: | 150 |
Study Start Date: | January 2009 |
Estimated Study Completion Date: | December 2012 |
Autism spectrum disorder (ASD) is a pervasive neuro-developmental disorder with prominent reciprocal social and communication impairment and restricted repetitive behavior or interest. Because ASD runs in family, because there is no effective biological treatment, and because early intervention can lead to better outcomes, ASD has been given a high priority for genetic and neurobiological study. Although abnormal brain structure has been reported, there is limited data regarding structural and functional dysconnectivity in autism. There is no such information in Asian population and no study has conducted using Diffusion Spectrum Imaging (DSI) to investigate the connectivity throughout the world. Moreover, no follow-up study has been done to examine the developmental changes of structural and functional connectivity. We thus propose this prospectively follow-up brain imaging study on ASD.
Specific Aims:
We will recruit 50 children with DSM-IV ASD (autistic disorder and Asperger's disorder) aged 3-15, their siblings, and 50 age-, sex-, and handedness-matached healthy controls. A number of instruments will be used to measure autistic symptoms, functional levels, and cognitive ability (i.e. ADI-R, ADOS, SCQ, SRS, and CAST; WISC-III (WPPSI-R, Bayley), DDST, CPM, and SPM; CPT, WCST, Cambridge Neuropsychological Test Automated Batteries). We will also look directly at the brain for structural and functional connectivity using the DSI and fMRI, respectively. We will repeat the assessments at a 2-year interval. The major tasks consisted of five parts: (1) 3 months—recruitment of subjects, researcher training, and pilot study; (2) 1 years 6 months—clinical, neuropsychological, genetic, DSI and fMRI assessments of 150 subjects; (3) 6 months—data analysis, reports to subjects, and manuscript preparation; (4) 1 years 6 months—same assessment of 150 subjects at a 2-year interval; (5) 4 months—data analysis, reports to subjects, and manuscript preparation.
We anticipate to establishing a cohort of 50 ASD and their siblings with complete clinical, neuropsychological, brain imaging, and genetic data for longitudinal study on ASD. Our findings will contribute to our understanding of the structural and functional dysconnectivity for ASD and whether dysconnectivity can be an endophenotype for ASD and used as a biomarker for early diagnosis of ASD.
Ages Eligible for Study: | 3 Years to 15 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
The sample will consist of 50 children with DSM-IV ASD (autistic disorder and Asperger's disorder) aged 3-15, their siblings, and 50 age-, sex-, and handedness-matached healthy controls.
Inclusion Criteria:
The inclusion criteria for the subjects with ASD are:
Exclusion Criteria:
The proband subjects will be excluded from the study if they currently meet criteria or have a history of the following condition as defined by DSM-IV:
Contact: Susan Shur-Fen Gau, MD, PhD | +886-2-23123456 ext 66802 | gaushufe@ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | |
Taipei, Taiwan |
Principal Investigator: | Susan Shur-Fen Gau, MD, PhD | Dept of Psychiatry, National Taiwan University Hospital |
Responsible Party: | National Taiwan University Hospital ( Susan Shur-Fen Gau ) |
Study ID Numbers: | 200807036R |
Study First Received: | September 18, 2008 |
Last Updated: | September 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00755430 |
Health Authority: | Taiwan: Department of Health |
autism spectrum disorders (ASD) structural and functional connectivity diffusion spectrum imaging (DSI) |
functional magnetic resonance imaging (fMRI) siblings repeated follow-up measurement |
Developmental Disabilities Child Development Disorders, Pervasive Mental Disorders Autistic Disorder Mental Disorders Diagnosed in Childhood |
Pathologic Processes Disease |