Effects of Calcium and Phytate on Zinc Absorption - Full Text View

Sponsored by:	USDA Grand Forks Human Nutrition Research Center
Information provided by:	USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier:	NCT00754390

Purpose

This study is determine the effects of dietary calcium and phytate on zinc absorption.

Condition	Intervention
Dietary Zinc Absorption	Behavioral: Moderate Ca low phytate Behavioral: High Ca low phytate Behavioral: Moderate Ca high phytate Behavioral: High Ca high phytate

MedlinePlus related topics: Calcium

Drug Information available for: Calcium gluconate Phytic acid Phytate sodium

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Prevention, Randomized, Open Label, Factorial Assignment, Bio-availability Study
Official Title:	Effects of Calcium and Phytate on Zinc Absorption

Further study details as provided by USDA Grand Forks Human Nutrition Research Center:

Primary Outcome Measures:

Quantitative measurement of zinc absorption [ Time Frame: 4 wk ] [ Designated as safety issue: No ]

Enrollment:	17
Study Start Date:	November 2005
Study Completion Date:	May 2006
Primary Completion Date:	May 2006 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental All subjects	Behavioral: Moderate Ca low phytate Two days of radiolabelled diet containing 700 mg Ca/d and 440 mg phytate/d Behavioral: High Ca low phytate Two days of radiolabelled diet containing 1900 mg Ca/d and 440 mg phytate/d Behavioral: Moderate Ca high phytate Two days of radiolabelled diet containing 700 mg Ca/d and 1800 mg phytate/d Behavioral: High Ca high phytate Two days of radiolabelled diet containing 1900 mg Ca/d and 1800 mg phytate/d

Arms

Assigned Interventions

1: Experimental

All subjects

Behavioral: Moderate Ca low phytate

Two days of radiolabelled diet containing 700 mg Ca/d and 440 mg phytate/d

Behavioral: High Ca low phytate

Two days of radiolabelled diet containing 1900 mg Ca/d and 440 mg phytate/d

Behavioral: Moderate Ca high phytate

Two days of radiolabelled diet containing 700 mg Ca/d and 1800 mg phytate/d

Behavioral: High Ca high phytate

Two days of radiolabelled diet containing 1900 mg Ca/d and 1800 mg phytate/d

Detailed Description:

Zinc absorption is tested from 2-d of consuming each of four diets with 65Zn isotope, followed by retention monitoring in a whole body scintillation counter for 4 wks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 wks.

Eligibility

Ages Eligible for Study:	21 Years to 50 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Average weight for height

Exclusion Criteria:

Medications other than birth control pills or hormone replacement therapy,
Pregnancy within last 6 months

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00754390

Locations

United States, North Dakota
USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States, 58202

Sponsors and Collaborators

USDA Grand Forks Human Nutrition Research Center

Investigators

Principal Investigator:

Janet R Hunt

USDA Grand Forks Human Nutrition Research Center

More Information

Responsible Party:	USDA Grand Forks Human Nutrition Research Center ( Janet R Hunt, Research Nutritiontist )
Study ID Numbers:	GFHNRC042
Study First Received:	September 16, 2008
Last Updated:	September 17, 2008
ClinicalTrials.gov Identifier:	NCT00754390
Health Authority:	United States: Federal Government

Keywords provided by USDA Grand Forks Human Nutrition Research Center:

dietary zinc absorption
dietary phytic acid
dietary calcium

Study placed in the following topic categories:

Calcium, Dietary
Zinc

ClinicalTrials.gov processed this record on January 13, 2009