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Sponsored by: |
Bispebjerg Hospital |
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Information provided by: | Bispebjerg Hospital |
ClinicalTrials.gov Identifier: | NCT00376207 |
Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects. Wether stroke patients can increase insulin sensitivity via physical exercise is not known.
Chronic low-grade inflammation is associated with an increased risk of stroke. Physical exercise has shown to increase IL-6 directly after exercise in untrained subjects. When fitness is increased in each subject then the peak IL-6 concentration after exercise decreases and so does the basal level of IL-6. It is not known whether stroke patients can increase physical activity level to a degree where chronic inflammation are decreased.
This study is designed to evaluate if physical exercise after stroke will increases insulin sensitivity and reduce low-grade chronic inflammation.
Stroke patients have been randomized to intervention with physical exercise or control in the ExStroke pilot trial and followed for 2 years. Using the study population from the ExStroke pilot trail blood samples will be obtained at the last control. Insulin sensitivity can be measured from fasting glucose and insulin using the Homeostasis Model Assessment (HOMA). Interleukin-6, TNF-alfa and CRP is measured to estimate chronic inflammation.
Condition | Intervention |
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Cerebral Infarction |
Behavioral: Physical exercise |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Single Blind, Dose Comparison, Single Group Assignment |
Estimated Enrollment: | 200 |
Study Start Date: | January 2006 |
Study Completion Date: | August 2007 |
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | LK-0102200601 |
Study First Received: | September 13, 2006 |
Last Updated: | October 16, 2007 |
ClinicalTrials.gov Identifier: | NCT00376207 |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Cerebral infarct physical exercise insulin sensitivity low grade chronic inflammation |
intervention HOMA PASE |
Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases Ischemia Brain Diseases Cerebrovascular Disorders |
Insulin Inflammation Necrosis Brain Ischemia Brain Infarction Infarction |
Pathologic Processes Nervous System Diseases Cardiovascular Diseases |