Konrad Noben-Trauth, Ph.D.
Chief
Section on Neurogenetics
Laboratory of Molecular Biology
NIDCD/NIH
5 Research Court, Room 2A31
Rockville, MD 20850
Phone: (301) 402–4223
Fax: (301) 435-4040
E-mail: nobentk@nidcd.nih.gov
Dr. Noben-Trauth received his Diploma in Biology from the University of Heidelberg in 1990. He was awarded a Heidelberg Scholarship to study at the University of Lexington, Kentucky, where he worked with Thomas Roszman on the function of beta-adrenergic receptors on human lymphocytes. He obtained his Ph.D. in 1994 from the University of Freiburg where he performed research with Karl-Heinz Klempnauer at the Max-Planck-Institute for Immunobiology on the myb gene family of transcription factors. He carried out postdoctoral research in the group of Patsy Nishina and Jürgen Naggert at The Jackson Laboratory, Bar Harbor, Maine, studying the genetics of obesity and deafness. He joined the NIDCD faculty in 1997 and became a Senior Investigator in 2004. His laboratory is interested in the genetics of hearing loss in mouse models.
Research Statement
The Section on Neurogenetics currently studies genetic variants that predispose to different forms of early- and late-onset hearing impairment in the mouse. In particular, we are interested in identifying genetic risk factors, genetic interactions, and molecular pathways that underlie hearing and hearing impairment in the young, adult and aging cochlea. Combinations of QTL mapping, positional cloning, micro-array analyses, and different mouse genetic resources such as inbred, heterogeneous, congenic, and recombinant inbred strains are being used.
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Lab Personnel
Nikoletta Charizopuolou, Ph.D., visiting fellow (Send e-mail)
Harold Neely, B.S., M.S., Biologist (Send e-mail)
Joseph Latoche, B.S., Biologist (Send e-mail)
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Selected Publications
- Chen Z, Montcouquiol M, Calderon R, Jenkins NA, Copeland NG, Kelley MW, Noben-Trauth K. Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of Corti. Journal of Neuroscience 28, 6633-6641, 2008.
- Calderon A, Derr A, Stagner BB, Johnson KR, Martin G, Noben-Trauth K. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hearing Research, 221, 44-58, 2006.
- Drayton M, Noben-Trauth K. Mapping quantitative trait loci for hearing loss in Black Swiss mice. Hearing Research 212, 128-139, 2006.
- Noben-Trauth K, Zheng QY, Johnson KR. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nature Genetics 35, 21-23, 2006.
- Di Palma F, Belyantseva IA, Kim HJ, Vogt TF, Kachar B, Noben-Trauth K. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc. Natl. Acad. Sci. USA, 99, 14994-14999, 2006.
- Di Palma F, Holme RH, Bryda EC, Belyantseva IA, Pellegrino R, Kachar B, Steel KP, Noben-Trauth K. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nature Genetics, 27, 103-107, 2006.
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Last updated: November 13, 2006 |
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