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Sponsors and Collaborators: |
Vanderbilt University National Institutes of Health (NIH) |
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Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00512369 |
Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.
Condition |
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Atherosclerosis |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Angiotensin, the Vascular Endothelium, and Fibrinolysis - The Effects of PAI-1 Transcriptional Regulation on Human Monocyte Function |
Estimated Enrollment: | 125 |
Study Start Date: | March 2006 |
Estimated Study Completion Date: | March 2008 |
The discovery and subsequent application of small interfering RNA (siRNA) methods to achieve individual gene silencing in mammalian cells is a robust method that is well-described and validated in mammalian cell culture systems. We will apply this technique to achieve post-transcriptional "silencing" of PAI-1 in monocytes obtained from otherwise healthy volunteers, and study the subsequent loss of this gene's function on the migratory capacity of these cells in the proposed in vitro experimental system. This concept has not yet been demonstrated in the literature, and if validated, would be a novel and fundamental description of the role of PAI-1 in human monocyte biology as related to the development of atherosclerosis.
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Mohan Sathyamoorthy, ND | 615-936-1719 | mohan.sathyamoorthy@vanderbilt.edu |
United States, Tennessee | |
Vanderbilt University Medical Center | Recruiting |
Nashville, Tennessee, United States, 37232 | |
Contact: Mohan Sathyamoorthy, MD 615-936-1719 mohan.saythya moorthy@vanderbilt.edu | |
Sub-Investigator: Douglas E Vaughan, MD |
Principal Investigator: | Mohan Sathyamoorthy, MD | Vanderbilt University |
Study ID Numbers: | 060286, NIH |
Study First Received: | August 3, 2007 |
Last Updated: | August 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00512369 |
Health Authority: | United States: Institutional Review Board; United States: Food and Drug Administration |
Metabolic pathways Atherosclerosis Monocyte Function |
Arterial Occlusive Diseases Atherosclerosis Plasminogen Activator Inhibitor 1 Vascular Diseases Arteriosclerosis |
Cardiovascular Diseases |