The neurodevelopmental and neurological disorders arising from Repeat Expansion at the FMR1 gene
Closing Date: None
Position Type:
Postdoctoral Fellow
Details:
A Postdoctoral position is available at NIH to study disease mechanisms arising from CGG•CCG-repeat expansion in the 5’ UTR of the FMR1 gene. Expansion at this locus results in Fragile X associated tremor and ataxia syndrome (FXTAS), Fragile X associated premature ovarian failure (FXPOF) and Fragile X mental retardation syndrome (FXS). Areas of interest include the mechanism of the unusual mutation responsible for these disorders, the RNA-mediated pathology believed to be responsible for FXTAS and FXPOF, the mechanism by which the gene is silenced in FXS (and how it can be reversed), and the molecular basis of the folate-sensitive chromosome fragility of expanded alleles. NIH offers an excellent work environment for Post-Doctoral Fellows. Candidates with a strong background in molecular biology and fewer than 5 years post-doctoral experience are encouraged to send their CV, bibliography and 3 letters of recommendation to ku@helix.nih.gov.
Contact Information
Karen Usdin
301-496-2189
ku@helix.nih.gov
Page last updated: December 16, 2008
