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AIDSinfo At-a-Glance Issue No. 44October 26, 2006
AIDSinfo.nih.gov is pleased
to provide you with a weekly update of highlights about what has happened
in the world of HIV/AIDS treatment, prevention, and research. We hope you
find this encapsulated view of HIV/AIDS news useful.
Latest News
UPDATED GUIDELINES
This guidelines revision represents a major rewriting
of the main document to improve its organization and readability. Because
the main document has been almost completely rewritten, there is no
highlighting of changes to either its text or tables.
The document’s
Appendix: Characteristics of
Available Antiretroviral Drugs, and Supplement I: Pediatric Antiretroviral Drug
Information, have also been updated. Changes to those sections are
highlighted.
Changes
in recommendations include:
·
Revised
guidelines on when to initiate therapy in antiretroviral-naïve children,
with recommendations for four age categories (< 12 months, 1 to < 4
years, 4 to 12 years, and > 13 years).
·
Revised
discussion and tables of rationale for antiretroviral drug choice for
antiretroviral-naïve children, with revised preferred and alternative
treatment regimen recommendations.
·
Revised
recommendations for adolescents, including issues related to drug dosing,
use of contraception, pregnancy, and transition into adult care.
·
Updated
Characteristics of Available Antiretroviral Drugs drug dosing
appendix and updated Supplement I: Pediatric Antiretroviral Drug
Information,
including information on newly approved antiretroviral agents, such as
darunavir, and new pediatric studies.
Also
new to the guidelines are:
·
Recommendations
for antiretroviral resistance testing for all antiretroviral-naïve
children prior to initiation of antiretroviral therapy.
·
New
section and table on monitoring of children on antiretroviral therapy and
management of antiretroviral toxicity/intolerance.
·
New
section on management of the treatment-experienced child.
·
New
section and tables on assessment and management of antiretroviral
treatment failure and choice of new antiretroviral regimen in children
with treatment failure.
·
New
section on therapeutic drug monitoring.
·
New
section on discontinuation or interruption of antiretroviral therapy.
·
Inclusion
of darunavir information.
Your
feedback is important! The
Working
Group on Antiretroviral Therapy and Medical Management of HIV-Infected
Children would like to hear your feedback on the latest revisions to
the
Guidelines for the Use of
Antiretroviral Agents in Pediatric HIV Infection. Please send your
comments with the subject line “Pediatric Comments” to AIDSinfoWebmaster@aidsinfo.nih.gov
by November.
ClinicalTrials.gov
Info
Please send comments or suggestions to ContactUs@aidsinfo.nih.gov
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