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Sponsored by: |
University of Schleswig-Holstein |
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Information provided by: | University of Schleswig-Holstein |
ClinicalTrials.gov Identifier: | NCT00791791 |
The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.
Condition | Intervention |
---|---|
Analgesia |
Procedure: standardized pain stimulus |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized |
Enrollment: | 24 |
Study Start Date: | August 2008 |
Study Completion Date: | November 2008 |
Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1
increasing remifentanil administration
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Procedure: standardized pain stimulus
a tetanic stimulus (30s, 50 Hz, 60mA) applied as standardized pain stimulus
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2
decreasing remifentanil concentration
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Procedure: standardized pain stimulus
a tetanic stimulus (30s, 50 Hz, 60mA) applied as standardized pain stimulus
|
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Whereas monitoring of depth of hypnosis, and muscle relaxation can be regarded as accepted, determination of the nociception is based on clinical signs like somatic or autonomic responses.
Recently, the multivariate surgical stress index (SSI)has been demonstrated to correlate with surgical stress intensity. Thus, SSI might be a useful variable to adjust analgesic drug administration in individual patients.
We want to investigate whether SSI is able to indicate nociception following standardized noxious stimulation during balanced sevoflurane - remifentanil anesthesia.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Germany, SH | |
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel | |
Kiel, SH, Germany, D-24105 |
Principal Investigator: | Matthias Gruenewald, MD | Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel |
Study Chair: | Berthold Bein, MD, DEAA | Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel |
Responsible Party: | University Hospital Schleswig Holstein ( PD Dr. Berthold Bein DEAA ) |
Study ID Numbers: | SSI-134-1 |
Study First Received: | November 14, 2008 |
Last Updated: | November 14, 2008 |
ClinicalTrials.gov Identifier: | NCT00791791 |
Health Authority: | Germany: Ethics Commission |
Anesthesia General Anesthetics Inhalation Stress measurement Surgical Stress Diagnostic Techniques and Procedures |
Remifentanil Stress Sevoflurane |