Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Fundacion Para La Investigacion Hospital La Fe University of Valencia Carlos III Health Institute |
---|---|
Information provided by: | Fundacion Para La Investigacion Hospital La Fe |
ClinicalTrials.gov Identifier: | NCT00791687 |
Premature infants are highly susceptible to oxidative stress because of the immaturity of their antioxidant defense system. The use of prenatal glucocorticosteroids administered to the mother improves respiratory function and overall outcome. The investigators hypothesize that prenatal glucocorticosteroids favor the expression and competence of the antioxidant defense system.
Condition |
---|
Oxidative Stress |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Prenatal Corticosteroids Enhance the Antioxidant Defense System in Extremely Low Gestational Age Neonates |
Enrollment: | 57 |
Study Start Date: | January 2003 |
Study Completion Date: | January 2005 |
Primary Completion Date: | January 2005 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
---|
PRENATAL CORTICOSTEROIDS
Extremely low gestational age neonates (<28 weeks gestation) whose mothers received full course of betamethasone before delivery.
|
NON PRENATAL CORTICOSTEROIDS
Extremely low gestational age neonates (<28 weeks gestation) whose mothers did not receive full course of betamethasone before delivery.
|
This is an observational study recruiting extremely low gestational age neonates (<28 weeks gestation) whose mothers received or not full scheduled prenatal glucocorticosteroids. Healthy term newly born infants acted as controls.
At birth cord blood were drawn for the following analytical determinations: reduced and oxidized glutathione; malondialdehyde; superoxide dismutase; catalase; glutathione peroxidase; glutathione reductase; glutathione s-transferase. In addition, first urine voided was collected for ortho-tyrosine/phenylalanine and 8-hydroxy-2-oxo-deoxyguanosine/2-deoxyguanosine determination. Analytical data and clinical outcomes are compared.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Extremely low gestational age neonates < 28 weeks gestation whose mothers received or not antenatal glucocorticosteroids.
Inclusion Criteria:
Exclusion Criteria:
Spain | |
Division of Neonatology; University Hospital La Fe | |
Valencia, Spain, 46009 |
Principal Investigator: | MAXIMO VENTO, PHD, MD | Valencian Agency of Health |
Responsible Party: | Valencian Agency for Health ( Maximo Vento ) |
Study ID Numbers: | PI08/0027 |
Study First Received: | November 13, 2008 |
Last Updated: | November 13, 2008 |
ClinicalTrials.gov Identifier: | NCT00791687 |
Health Authority: | Spain: Comité Ético de Investigación Clínica |
Antioxidant enzymes Glutathione Oxidative stress Prematurity |
Respiratory distress Non enzymatic antioxidant defense system Enzymatic antioxidant defense system |
Stress |