Inclusion Criteria:

• Patients with normal hepatic function:Normotensive at screening, with supine (5 minutes) blood pressure between the range of 95 to 160 mmHg systolic, inclusive, and 55 to 95 mmHg diastolic, inclusive, demographically comparable to the hepatic impairment group with respect to age, weight, sex, and ethnicity and healthy on the basis of a prestudy physical examination, medical history, ECG, and laboratory results of blood biochemistry, hematology, and urinalysis performed within 3 weeks before study drug administration. If the results of the biochemistry or hematology tests or the urinalysis are not within the laboratory's reference ranges, the patient can be included only if the investigator judges that the deviations are not clinically significant
• Patients with moderate hepatic impairment: Blood pressure controlled and stable on antihypertensive agents, stable hepatic disease with laboratory and clinical findings that support the diagnosis of hepatic impairment, otherwise healthy on the basis of a prestudy physical examination, medical history, ECG, and laboratory results of blood biochemistry, hematology, and urinalysis performed within 3 weeks before study drug administration. Patients with controlled hypertension and those problems directly associated with the primary diagnosis of hepatic impairment may be included. Patients with stable, mild, chronic concurrent diseases, such as degenerative joint disease, Type II diabetes, or thyroid conditions requiring thyroid replacement therapy or surgery, may be included. If the results of the biochemistry or hematology tests or the urinalysis are not within the laboratory's references ranges, the patient can be included only if the investigator judges that the deviations are not clinically significant. Laboratory results related to the patient's underlying condition may be outside of the normal ranges. (Serum bilirubin, albumin, and prothrombin time will be assessed individually)
• Total score of Child-Pugh's classification will be between 7 and 9, inclusive
• Concomitant medications to treat underlying disease states or medical conditions related to hepatic insufficiency are allowed. Patients have to be on a stable dose of medication and/or treatment regimen 2 months before the study, as well as during the study

Exclusion Criteria:

• Patients with normal hepatic function:Has any significant history or presence of hepatic disease or has positive serology result for hepatitis B surface antigen (HBsAg) or anti-hepatitis C virus (as determined by a multi-antigen enzyme immunoassay)
• At screening, sustained drops in systolic (>20 mmHg) or diastolic (>10 mmHg) blood pressure after standing for at least 2 minutes which are not associated with an increase in pulse rate of >15 beats per minute
• Is taking, or has taken, any prescribed or over-the-counter drug (including vitamins and herbal supplements) within 2 weeks before study drug administration (with the exception of paracetamol, hormonal contraceptives, and hormone replacement therapy)
• Patients with moderate hepatic impairment: Has any clinically significant laboratory abnormality except those parameters influenced by hepatic impairment, has a score of 3 or 4 for hepatic encephalopathy as determined by the result of the Number Connection Test, has severe ascites and/or pleural effusion, has serology result positive for HBsAg, has acute exacerbation of liver disease, as indicated by worsening clinical signs of hepatic impairment, or by an increase of more than 50% in total bilirubin or prothrombin time in the preceding 3 months (as far as information is available)