Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD

This study is not yet open for participant recruitment.

Verified by Sheba Medical Center, November 2008

Sponsors and Collaborators:	Sheba Medical Center University of Haifa Israel Science Foundation
Information provided by:	Sheba Medical Center
ClinicalTrials.gov Identifier:	NCT00790634

Purpose

The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive disorder, by examining performance on cognitive tasks involving cognitive flexibility, decision-making, and attentional bias.

Condition
Parkinson's Disease Obsessive-Compulsive Disorder

Genetics Home Reference related topics: familial paroxysmal nonkinesigenic dyskinesia Parkinson disease

MedlinePlus related topics: Obsessive-Compulsive Disorder Parkinson's Disease

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Characterizing Mechanisms of Fronto-Subcortical Dysfunction: A Comparison Between Parkinson's Disease and Obsessive-Compulsive Disorder

Further study details as provided by Sheba Medical Center:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	100
Study Start Date:	December 2008
Estimated Study Completion Date:	December 2011
Estimated Primary Completion Date:	December 2011 (Final data collection date for primary outcome measure)

Groups/Cohorts
Parkinson's Disease Patients with idiopathic Parkinson's disease
Obsessive-compulsive disorder Individuals with a diagnosis of obsessive-compulsive disorder
OCD controls Healthy controls, matched in age and number to obsessive-compulsive group
PD controls Healthy controls, matched in age and number to Parkinson's disease group

Eligibility

Ages Eligible for Study:	16 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

private and hospital-based clinics, healthy volunteers

Criteria

Inclusion Criteria:

idiopathic PD or
OCD
for control group - age-matched to study groups

Exclusion Criteria:

psychotic symptoms (past or present)
head injury with loss of consciousness
other neurological conditions (excepting PD in PD group)
for OCD group - use of dopaminergic medications

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00790634

Contacts

Contact: Sharon Hassin, MD	97235305791	shassin@post.tau.ac.il
Contact: Sari Meril, M.Sc	972

Sponsors and Collaborators

Sheba Medical Center

University of Haifa

Israel Science Foundation

More Information

Responsible Party:	Sheba Medical Center ( Dr. Sharon Hassin, principal investigator )
Study ID Numbers:	SHEBA-08-5473-SH-CTIL
Study First Received:	November 12, 2008
Last Updated:	November 12, 2008
ClinicalTrials.gov Identifier:	NCT00790634
Health Authority:	Israel: Ministry of Health

Study placed in the following topic categories:

Ganglion Cysts
Anxiety Disorders
Movement Disorders
Mental Disorders
Parkinson Disease
Basal Ganglia Diseases

Central Nervous System Diseases
Parkinsonian Disorders
Neurodegenerative Diseases
Brain Diseases
Obsessive-Compulsive Disorder

Additional relevant MeSH terms:

Pathologic Processes
Disease
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009