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Sponsors and Collaborators: |
Stanford University National Institutes of Health (NIH) |
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Information provided by: | Stanford University |
ClinicalTrials.gov Identifier: | NCT00568867 |
The purpose of this study is to evaluate markers of immune response in human tumor samples.
Condition |
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Cancer |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Evaluation of Preexisiting Immunity Markers in Human Tumor Tissue Sample |
Estimated Enrollment: | 300 |
Study Start Date: | September 2006 |
Cancer immunotherapy has been shown to be effective in isolated instances, but ineffective in most patients. The reason for this inconsistency, and the conditions necessary for successful immunotherapy, are not well understood. Our studies in animal tumor models indicate that the effectiveness of IL-12-based immunotherapy depends upon the presence of a preexisting immune response to the tumor. The presence of T cell infiltrates and IFN-gamma expression in tumor indicate such an immune response. We therefore plan to evaluate the existing immune response in human tumor samples in an effort to identify those patients most likely to respond to therapy with IL-12.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:Any adult patient with a tumor who is scheduled to undergo surgery to either remove or biopsy the tumor.
 Exclusion Criteria:Patients without tumor and pediatric patients (children) will be excluded.
Contact: Robin Malone Cisco | (650) 724-5570 | rcisco@stanford.edu |
United States, California | |
Stanford University School of Medicine | Recruiting |
Stanford, California, United States, 94305 | |
Contact: Robin Malone Cisco 650-724-5570 rcisco@stanford.edu | |
Contact: Cancer Clinical Trials Office (650) 498-7061 | |
Principal Investigator: Jeffrey A. Norton | |
Sub-Investigator: Kangla Tsung |
Principal Investigator: | Jeffrey A. Norton | Stanford University |
Study ID Numbers: | SU-11072007-830, 97310, NCT00568867, VAR0018 |
Study First Received: | December 4, 2007 |
Last Updated: | October 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00568867 |
Health Authority: | United States: Institutional Review Board |