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Sponsored by: |
Chosun University Hospital |
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Information provided by: | Chosun University Hospital |
ClinicalTrials.gov Identifier: | NCT00568711 |
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.
In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.
Condition | Intervention |
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Scrub Typhus |
Drug: doxycycline Drug: rifampin |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus |
Estimated Enrollment: | 476 |
Study Start Date: | September 2006 |
Estimated Study Completion Date: | December 2009 |
Arms | Assigned Interventions |
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1: Active Comparator
a 5-day course of daily 200-mg doses of doxycycline
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Drug: doxycycline
a 5-day course of 100 mg bid doses of doxycycline
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2: Active Comparator
a 5-day course of daily 600-mg doses of rifampin
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Drug: rifampin
a 5-day course of daily 600-mg doses of rifampin
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Inclusion criteria were:
Exclusion Criteria:
The exclusion criteria were:
Contact: Dong-Min Kim, Prof | 82-62-220-3108 | drongkim@chosun.ac.kr |
Korea, Republic of, Jeollanamdo | |
Chosun University Hospital | Recruiting |
Gwang-Joo, Jeollanamdo, Korea, Republic of, 501-717 | |
Contact: Dong-Min Kim, Prof 82-62-220-3108 drongkim@chosun.ac.kr |
Study Director: | Namsoo Cho | Director of Chosun University Hospital |
Responsible Party: | Department of Internal Medicine, Chosun University College of Medicine ( Dong-Min Kim ) |
Study ID Numbers: | IRB043-31, IRB043-31 |
Study First Received: | December 5, 2007 |
Last Updated: | December 5, 2007 |
ClinicalTrials.gov Identifier: | NCT00568711 |
Health Authority: | Republic of Korea: Chosun University Institutional Ethics Board |
Doxycycline, Rifampin Scrub typhus. |
Bacterial Infections Lice Infestations Rifampin Typhus Typhus, Epidemic Louse-Borne Rickettsia Infections |
Rickettsiosis Rickettsial disease Scrub Typhus Doxycycline Gram-Negative Bacterial Infections |
Anti-Infective Agents Antiprotozoal Agents Molecular Mechanisms of Pharmacological Action Rickettsiaceae Infections Enzyme Inhibitors Pharmacologic Actions Antibiotics, Antitubercular |
Anti-Bacterial Agents Antimalarials Antiparasitic Agents Therapeutic Uses Antitubercular Agents Nucleic Acid Synthesis Inhibitors Leprostatic Agents |