Morphine Analgesia in Patients With Acute Appendicitis - Full Text View

Sponsored by:	Tehran University of Medical Sciences
Information provided by:	Tehran University of Medical Sciences
ClinicalTrials.gov Identifier:	NCT00477061

Purpose

The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Condition	Intervention	Phase
Appendicitis	Drug: Morphine	Phase IV

MedlinePlus related topics: Appendicitis

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Supportive Care, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Official Title:	Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis

Further study details as provided by Tehran University of Medical Sciences:

Primary Outcome Measures:

Pain Intensity

Secondary Outcome Measures:

Diagnostic Accuracy

Enrollment:	71
Study Start Date:	January 2004
Study Completion Date:	March 2005

Detailed Description:

Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

Eligibility

Ages Eligible for Study:	13 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

clinical signs of acute appendicitis
planned for appendectomy
supposed to wait for at least 1 hour in the ED before operation

Exclusion Criteria:

suspicion to perforated appendicitis
being under the age of 13
pregnancy (according to history and ß-HCG result)
opium addiction
systolic blood pressure of less than 90 mmHG
known cases of chronic obstructive pulmonary disease (COPD)
known sensitivity to morphine
history of sickle cell disease
self administration of analgesics before enrollment
refusal to participate

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00477061

Locations

Iran, Islamic Republic of
Sina General Hospital
Tehran, Iran, Islamic Republic of

Sponsors and Collaborators

Tehran University of Medical Sciences

Investigators

Principal Investigator:

Asieh Golozar, MD

Tehran University of Medical Sciences

More Information

Publications indexed to this study:

Amoli HA, Golozar A, Keshavarzi S, Tavakoli H, Yaghoobi A. Morphine analgesia in patients with acute appendicitis: a randomised double-blind clinical trial. Emerg Med J. 2008 Sep;25(9):586-9.

Study ID Numbers:	AG11
Study First Received:	May 20, 2007
Last Updated:	May 20, 2007
ClinicalTrials.gov Identifier:	NCT00477061
Health Authority:	Iran: Ministry of Health

Keywords provided by Tehran University of Medical Sciences:

MORPHINE
ANALGESIA
ACUTE APPENDICITS

Study placed in the following topic categories:

Morphine
Digestive System Diseases
Gastrointestinal Diseases

Appendicitis
Intestinal Diseases
Gastroenteritis

Additional relevant MeSH terms:

Sensory System Agents
Therapeutic Uses
Physiological Effects of Drugs
Central Nervous System Depressants
Narcotics
Peripheral Nervous System Agents

Analgesics
Central Nervous System Agents
Pharmacologic Actions
Analgesics, Opioid
Cecal Diseases

ClinicalTrials.gov processed this record on January 16, 2009