John A. Hanover Research Images
![Calmodulin-dependent nuclear import](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/23C3F28C-BDAD-4D93-948A-6E4630C26BC7/0/calmodulinHanover.jpg)
Calmodulin-dependent nuclear import
![The Hexosamine Signaling Pathway](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/A15288DA-0B03-4520-9384-FDEB24D65A65/0/hexosamineHanover.jpg)
The Hexosamine Signaling Pathway: The Nutrient Sensing Hexosamine signaling pathway terminating in O-GlcNAc addition and removal. This pathway may be deregulated in human diseases such as diabetes me
![OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cells](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/5F684659-5ED2-43A4-8CC1-7065C63E1A6C/0/OGTHanover.jpg)
OGT isoforms are differentially targeted to nucleus and mitochondria in Hela cells: Using an antisera to OGT (green) and mitotracker (red) OGT isoforms were shown to be present in nucleus and mitochondria.
![Structure of the TPR domain of OGT has similarities to Importin alpha](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/C0E1EA3C-AD7A-4762-BBA1-C564021364E7/0/OGTstructureHanover.jpg)
Structure of the TPR domain of OGT has similarities to Importin alpha: The X-Ray structure of OGT reveals that is dimer and has an 'asparagine ladder' motif similar to that oportin alpha. The OGT TPR domain allows recognition of a large number of intracellular targets.
![O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegans](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/6B1E037B-3958-485C-8CFE-A448E43814DD/0/dauer2.jpg)
O-GlcNAc cycling modulates insulin signaling and Dauer in C. elegans: In C. elegans, insulin-like signaling regulates longevity, stress response and the entry into the diapause state termed dauer. Knockout of ogt-1 leads to reduced dauer formation (insulin hypersensitivity) while knockout of oga-1 results in enhanced dauer formation (insulin resistance).
![Hexosamine Signaling and Taopathy](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/888B36F4-C277-4FB3-A0F1-28D0653F3D1B/0/fig2hanover.jpg)
Hexosamine Signaling and Taopathy: Expression of muttated human tau (V337M) in C. elegans causes a severe uncoordinated motion (unc) phenotype associated with neuronal cell death. When this mutation is crossed to ogt-1(ok430), this phenotype is largely corrected.
![Ran and Calmodulin - Dependent Nuclear Transport](https://webarchive.library.unt.edu/eot2008/20090130204536im_/http://www2.niddk.nih.gov/NR/rdonlyres/9BF41C92-7A2F-44F2-8CC5-ED397C7D8DA8/0/fig3.gif)
Figure 3: Ran and Calmodulin - Dependent Nuclear Transport
Page last updated: December 16, 2008