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Rapid Response Surveillance Studies
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Outcomes - Secondary/Late Effects of Treatment

Secondary or late effects are conditions that arise as a consequence of the diagnosis and treatment of cancer. The number of cancer survivors in the US is increasing and this research seeks to understand the impact of cancer and cancer treatment on survivors' health status and health outcomes. Survivors are faced with issues related to follow-up care, long term surveillance for late effects of treatment, and the appropriate follow-up and treatment for these late effects.

RRSS investigators are conducting studies to:

  • investigate pregnancy outcomes in childhood cancer survivors and in cervical cancer survivors;
  • examine the health status of men diagnosed with testicular cancer and long-term complications resulting from treatment;
  • examine secondary tumors related to cancer treatment and the natural history of prostate and colon cancer.

Registries Funded to Conduct these Studies

Atlanta (Metropolitan)
Detroit (Metropolitan)
Los Angeles
New Mexico
Seattle (Puget Sound)

Key Findings

Treatment of cervical carcinoma in situ (CIS) may have an impact on subsequent pregnancy outcomes. The risk of preterm delivery increased after conization for CIS but did not increase when women with CIS had other procedures. Treatments investigated included no therapy, dilation and curettage or endocervical curettage, cryosurgery or laser vaporization, and conization (El-Bastawissi, 1999).

Data collected on long-term survivors of testicular cancer indicate that some therapies may have complications some time after the initial treatment. However, the feasibility study does not have sufficient numbers to draw conclusions.

Future Use

Investigators will pursue RO1 funding based on feasibility studies conducted with this mechanism.


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