Position Available in the CCR Details
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The NCI Center for Cancer Research is part of the National Institutes
of Health (NIH), U.S. Department of Health and Human Services. |
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| Position Title: | Postdoctoral Fellow |
| Contact Name: | Vinay K. Pathak, Ph.D. |
| Contact Phone: | 301-846-1710 |
| Contact Fax: | 301-846-6013 |
| Contact E-mail: | vpathak@ncifcrf.gov |
| Branch/Laboratory/Program: | HIV DRP Retroviral Replication Laboratory |
| Investigator's Home Page: | http://home.ncifcrf.gov/hivdrp/Pathak.html |
| Number of Positions Available: | 1 |
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Research Area Key Words: |
HIV-1 replication and drug resistance |
| CV Required? | Yes |
| Number References Required: | 3 |
| Publications List Required? | Yes |
| Position Description: | Our goal is to understand how HIV-1 replicates and how its interactions with the host cell influence its replication. We are active in three major research areas. First, we are defining the structure and function of host restriction factor APOBEC3G and 3F proteins. Specific research projects include the mechanisms by which APOBEC proteins inhibit HIV-1 replication, structural determinants of interaction between HIV-1 Vif protein and APOBEC proteins, mechanisms of APOBEC protein incorporation into virions, biochemical characterization of APOBEC proteins, and their in vivo regulation. Second, we are elucidating mechanisms by which HIV-1 reverse transcriptase (RT) acquires resistance to RT inhibitors. Our specific research aims are to further define the role of the C-terminal connection and RNase H domains of RT in antiviral drug resistance in subtype B as well as non-B subtypes of HIV-1. Third, we are exploring the in vivo mechanisms of reverse transcription by using a novel quantitative strand-specific amplification technology that we recently developed. Further details and a list of relevant publications can be found at http://home.ncifcrf.gov/hivdrp/Pathak.html. |
| Experience Required: | Postdoctoral positions are currently available to participate in these studies. Interested candidates should have a Ph.D. with a strong background in molecular virology and/or molecular biology and biochemistry. |
| Additional Information: |
Candidates should submit a cover letter, CV including bibliography, and contact information for three references to:
Vinay K. Pathak, Ph.D. Viral Mutation Section HIV Drug Resistance Program National Cancer Institute NCI-Frederick P.O. Box B, Building 535, Room 334 Frederick, MD 21702-1201 E-mail: vpathak@ncifcrf.gov |
| Location: | NCI-Frederick |
 NIH
is part of the Department of Health and Human Services |
