Clinical Trials
Depression
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
Effectiveness of a Web-Based Prevention Program for Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of a Web-based program in preventing postpartum depression. Ages 18-60. Location in San Francisco, CA.
- Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder.
Interventional study. Objective: To test the efficacy of riluzole in youth with bipolar disorder Study population: Youth, ages 9-17, with DSM-IV bipolar disorder, who have failed to respond to two adequate trials of medication, one with an atypical antipsychotic medication, and the second with either a mood stabilizing medication or a second atypical antipsychotic medication. Ages 9-17. Location in Bethesda, MD.
- Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression.
Interventional study. This study will examine whether combined use of an antidepressant medication and the medication nimodipine reduces risk of depression relapse in patients with vascular depression. Ages 50 and over. Location in Pittsburgh, PA.
- Predicting Effectiveness of Light Treatment for Winter Seasonal Affective Disorder.
Evaluation study. This study will evaluate a possible tool for predicting future effectiveness of bright light in treating seasonal affective disorder, winter subtype, and will examine secondary effects of bright light on cardiovascular risk factors. Ages 18-64. Location in Baltimore, MD.
- Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics.
Interventional study. This study will determine whether combination treatment driven by patient choice is better than standardized medication treatment at retaining and improving Hispanic patients with major depressive disorder. Ages 18-65. Location in New York, NY.
- AZD2327 to Treat Anxious Major Depression.
Interventional study. This study will examine the safety and effectiveness of an experimental drug called AZD2327 for treating anxious major depressive disorder. Ages 18-65. Location in Bethesda, MD.
- p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram.
Evaluation study. This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa). Ages 18-65. Location in Bethesda, MD.
- Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression.
Interventional study. This study will examine changes in brain dopamine transporter activity before and after antidepressant therapy. Ages 18-65. Location in Philadelphia, PA.
- Effects of Cognitive Behavioral Therapy on Brain Serotonin Activity in People With Depression.
Interventional study. This study will examine changes in brain serotonin activity in people with depression before and after they receive cognitive behavioral therapy. Ages 18-65. Location in Philadelphia, PA.
- Effectiveness of Group Interpersonal Psychotherapy in Treating Women With Prenatal Depression.
Interventional study. This study will evaluate the effectiveness of group interpersonal psychotherapy for preventing postpartum depression in pregnant women with depression and for improving healthy outcomes in their babies. Ages 18-40. Location in New York, NY.
- Effectiveness of Emotion-Focused Cognitive Behavioral Therapy for Treating Adolescents With Emotional Disorders.
Interventional study. This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders. Ages 12-17. Location in Miami, FL.
- Effectiveness of Adding Relapse Prevention Cognitive Behavioral Therapy to Fluoxetine Treatment for Pediatric Major Depressive Disorder.
Interventional study. This study will compare the effectiveness of fluoxetine alone with the effectiveness of fluoxetine with cognitive behavioral therapy in increasing recovery and preventing relapse in youth with major depressive disorder. Ages 8-17. Location in Dallas, TX.
- Effectiveness of Internet-Based Cognitive Behavioral Therapy for Treating Mothers With Depression.
Interventional study. This study will evaluate the effectiveness of an Internet-based cognitive behavioral therapy program in treating mothers with depression who have young children. Location in Eugene, OR.
- Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression.
Interventional study. This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression. Ages 60 and over. Location in Los Angeles, CA.
- Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of antidepressant medication alone and interpersonal psychotherapy alone in treating women with postpartum depression. Ages 18-65. Locations in Iowa City, IA; Providence, RI.
- Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse.
Interventional study. This study will evaluate the effectiveness of an interpersonally oriented treatment program called Reach Out for a Safe Environment in preventing depression and post-traumatic stress disorder in low-income pregnant women who have experienced recent partner abuse. Ages 18-40. Location in Providence, RI.
- Depression Prevention for Pregnant Women on Public Assistance.
Interventional study. This study will evaluate the effectiveness of an interpersonal therapy treatment called the Postpartum Prevention Program in preventing the development of postpartum depression in pregnant women who are financially disadvantaged. Ages 18-40. Locations in Pawtucket, RI; Providence, RI; Woonsocket, RI.
- Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
- Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease.
Interventional study. This study will evaluate the effectiveness of problem-solving therapy combined with treatment adherence procedures in treating older people with major depression and chronic obstructive pulmonary disease. Ages 50-95. Location in White Plains, NY.
- Effectiveness of Cognitive Behavioral Therapy in Reducing Depressive Symptoms in Physically Ill Youth.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy with supportive nondirective therapy in reducing emotional distress and improving functioning in youth with inflammatory bowel disease and depression. Ages 9-17. Locations in Boston, MA; Pittsburgh, PA.
- Effectiveness of Parent-Child Interaction and Emotion Development Therapy in Treating Preschool Children With Depression.
Interventional study. This study will evaluate the effectiveness of parent-child interaction therapy that includes an emotion development component in treating depression in preschool children. Ages 3-6. Location in St. Louis, MO.
- Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.
- Combining Medications to Enhance Depression Outcomes.
Interventional study. This study will compare whether a combination of antidepressant medications is better than one antidepressant medication alone when given as initial treatment for people with chronic or recurrent major depressive disorder. Ages 18-75. Locations in Tuscaloosa, AL; Harbor City, CA; Los Angeles, CA; San Diego, CA; Chicago, IL; Wichita, KS; Salem, MA; Ann Arbor, MI; Chapel Hill, NC; New York, NY; Tulsa, OK; Pittsburgh, PA; Nashville, TN; Dallas, TX; Richmond, VA.
- Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women.
Interventional study. This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight. Ages 21-65. Location in Worcester, MA.
- Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression.
Interventional study. This study will evaluate the effectiveness of adding motivational interviewing to antidepressant treatment for major depressive disorder in Hispanic adults. Ages 18-79. Location in New York, NY.
- Effectiveness of Cognitive Behavioral Therapy in Improving Adherence and Depressive Symptoms in People With Diabetes.
Interventional study. This study will evaluate the effectiveness of cognitive behavioral therapy (CBT) in treating people with depression and type 2 diabetes. Ages 18-70. Location in Boston, MA.
- Effectiveness of Case Management Versus Case Management Plus Problem-Solving Therapy to Treat Depression in Low-Income Elders.
Interventional study. This study will compare the effectiveness of case management combined with problem-solving therapy (CM-PST) versus case management (CM) alone for assisting elderly people with depression. Ages 65-95. Locations in San Francisco, CA; White Plains, NY.
- Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment.
Interventional study. This study will evaluate the effectiveness of escitalopram to prevent depression in head and neck cancer patients receiving treatment. Ages 19 and over. Location in Omaha, NE.
- Evaluating a Behavioral Activities Treatment Program for Depressed Nursing Home Residents.
Interventional study. This study will evaluate whether a behavioral activities treatment program improves symptoms of depression in nursing home residents. Location in Louisville, KY.
- Evaluating the Effects of Stress in Pregnancy.
Evaluation study. This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy. Ages 18-45. Location in Atlanta, GA.
- Pharmacogenomics of Antidepressant Response in Children and Adolescents.
Evaluation study. This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications. Ages 7-17. Location in Durham, NC.
- Omega-3 Fatty Acids for Treating Adults With Major Depression.
Interventional study. This study will test the effectiveness of two different kinds of omega-3 fatty acid dietary supplements in treating the symptoms of major depression. Ages 18-80. Location in Los Angeles, CA.
- Antidepressant Medication and Cognitive Behavioral Therapy to Help HIV Infected Adults With Depression to Adhere to Antiretroviral Therapy.
Interventional study. This study will compare the effectiveness of antidepressant therapy alone versus antidepressant therapy combined with cognitive behavioral therapy in helping HIV infected adults with depression to take their medications on schedule. Ages 18-60. Location in Torrance, CA.
- Effectiveness of Telephone Versus Face-to-Face Administered Cognitive Behavioral Therapy in Treating People With Depression.
Interventional study. This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression. Ages 18 and over. Location in Chicago, IL.
- Antidepressant Effects of NR2B in Major Depression.
Interventional study. Purpose : This study will determine whether MK-0657, a Selective NR2B Antagonist, can quickly improve symptoms of depressed mood, psychomotor retardation, poor motivation and reduced enjoyment of things in patients with major depression. Ages 18-55. Location in Bethesda, MD.
- Reducing Health Risk Behavior and Improving Health in Adolescents With Depression.
Interventional study. This study will determine the effectiveness of a health education intervention in reducing health risk behavior and improving health in adolescents with depression. Ages 13-18. Location in Los Angeles, CA.
- Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment.
Interventional study. This study will use pre-treatment positron emission topography and functional magnetic resonance imaging scans of the brain to predict the most effective antidepressant treatment for people with major depressive disorder. Ages 18-65. Location in New York, NY.
- Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers.
Interventional study. This study will aim to prevent postpartum depression in pregnant teenagers through an interpersonal therapy-based program. Ages 12-18. Location in Providence, RI.
- Paroxetine/Bupropion in Suicide Attempters/Ideators With Major Depression.
Interventional study. This study will compare the effectiveness of two antidepressant medications in treating depression in people who have attempted suicide or are currently experiencing suicidal ideation. Ages 18-75. Location in New York City, NY.
- Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders.
Evaluation study. This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Ages 18-50. Location in Bethesda, MD.
- Antidepressant Safety in Kids Study.
Evaluation study. This study will evaluate the risks and benefits of treatment with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor in children and adolescents with a pre-specified anxiety disorder, depressive disorder, eating disorder, or obsessive-compulsive disorder. Ages 7-17. Location in Durham, NC.
- Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy.
Interventional study. This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes. Ages 21-45. Location in Ann Arbor, MI.
- The Antidepressant Efficacy of the Anticholinergic Scopolamine.
Interventional study. A previous study showed that the intravenous administration of scopoalmine produces antidepressant effects. Ages 18-55. Location in Bethesda, MD.
- Supportive Therapy Versus Problem Solving Therapy in Treating Depressed, Cognitively Impaired Older Adults.
Interventional study. This study will evaluate the effectiveness of problem solving therapy in treating depressed, cognitively impaired older adults. Ages 65 and over. Location in White Plains, NY.
- Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients.
Interventional study. The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients. Ages 18-65. Location in Bethesda, MD.
- Effectiveness of a Telephone-Delivered Behavioral Treatment to Improve the Quality of Life of Older Adults With HIV.
Interventional study. This study will evaluate the effectiveness of a telephone-delivered coping improvement group intervention in improving quality of life in older adults with HIV. Ages 50 and over. Location in Athens, OH.
- Motivational Interviewing to Improve Medication Adherence Among Hispanic Adults With Depression.
Interventional study. This study will determine the effectiveness of motivational interviewing in improving antidepressant medication adherence among Hispanics. Ages 18-65. Location in New Brunswick, NJ.
- Interpersonal Psychotherapy for Depression in People With Heart Failure.
Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy and behavioral activation techniques in treating depression in people with congestive heart failure. Ages 55 and over. Location in Iowa City, IA.
- Evaluating the Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment.
Interventional study. This study will determine the effectiveness of an antidepressant in preventing or reducing depressive symptoms in people with melanoma who are receiving Interleukin-2 (IL-2) treatment. Ages 18-75. Location in Atlanta, GA.
- Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy.
Interventional study. This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression. Ages 18 and over. Location in San Francisco, CA.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder.
Interventional study. This study will examine whether mitochondrial function is impaired in patients with bipolar disorder. Ages 18-65. Location in Bethesda, MD.
- Prevention of Depression in Spouses of People With Cognitive Impairment.
Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or significant others of people with mild cognitive impairment. Ages 18 and over. Location in Pittsburgh, PA.
- Integrated Parent Training for Treating Depression in Mothers of Children With Attention Deficit Hyperactivity Disorder.
Interventional study. This study will determine the effectiveness of integrated parent training versus standard behavioral parent training in treating depression and stress in mothers of children with attention deficit hyperactivity disorder (ADHD). Ages 6 and over. Location in College Park, MD.
- Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease.
Interventional study. This study will evaluate the effectiveness of atomoxetine in reducing symptoms of depression in people with Parkinson's disease. Ages 30-79. Location in Philadelphia, PA.
- Identification and Therapy of Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women. Ages 18 and over. Location in Pittsburgh, PA.
- Bipolar II Depression: Lithium, SSRI, or the Combination.
Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Palo Alto, CA; Mason, OH.
- Genetics of Recurrent Early Onset Major Depression.
Evaluation study. This study will identify specific genes that may cause a predisposition to depression in some families. Ages 21-70. Locations in Palo Alto, CA; Washington, DC; Iowa City, IA; Chicago, IL; Baltimore, MD; New York, NY.
- Effectiveness of Interpersonal Psychotherapy in Treating Pregnant Women With Depression.
Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy in treating pregnant women with depression. Ages 18-47. Location in New York, NY.
- Improving Sleep and Psychological Functioning in People With Depression and Insomnia.
Interventional study. This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia. Ages 18-70. Location in Winston-Salem, NC.
- Understanding Brain Reward Responses in Individuals With Major Depressive Disorder.
Evaluation study. This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD). Ages 18-64. Locations in Boston, MA; Cambridge, MA; Charlestown, MA.
- Characterizing Psychological Consequences of Childhood Trauma.
Evaluation study. This study will characterize the mental health consequences of early-life trauma. Ages 18-45. Location in Atlanta, GA.
- Determining Changes in Brain Structure Associated With Symptoms of Late-Life Depression.
Evaluation study. This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression. Ages 55 and over. Location in Pittsburgh, PA.
- Maintenance Treatment of Bipolar Depression.
Interventional study. This study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression. Ages 18 and over. Location in San Antonio, TX.
- Family Cognitive Behavioral Therapy for Preventing Depression in Children.
Interventional study. This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression. Ages 10 and over. Location in Nashville, TN.
- Cognitive Therapy for Treating Depression and Preventing Relapse.
Interventional study. This study will compare the effectiveness of cognitive therapy versus antidepressant medication in treating depression and preventing relapse in individuals with recurrent depression. Ages 18-70. Location in Pittsburgh, PA.
- Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram.
Interventional study. This study will evaluate changes in brain energy metabolism due to treatment with escitalopram in people with major depressive disorder. Ages 18-65. Location in Boston, MA.
- Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence.
Interventional study. This study will determine whether trauma-focused cognitive behavioral therapy (TF-CBT) is more effective than child-centered therapy (CCT) in reducing post traumatic stress disorder (PTSD) in children exposed to domestic violence (DV). Ages 7-14. Location in Pittsburgh, PA.
- Effect of Family-Based Prevention on Children of Depressed Parents.
Interventional study. This study will test the Protecting Families Program, a 10-week prevention program for depressed parents and their pre-teenage children, by comparing the effectiveness of the program versus parent training alone. Ages 9 and over. Location in Philadelphia, PA.
- A Clinic-Based Prevention Program for Families of Depressed Mothers.
Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.
- Magnetic Brain Stimulation for the Treatment of Adult Depression.
Interventional study. This study will evaluate the safety and effectiveness of magnetic brain stimulation for the treatment of major depression in depressed adults with moderate treatment resistance. Ages 21-70. Locations in Atlanta, GA; New York, NY; Charleston, SC; Seattle, WA.
- Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With Depression.
Interventional study. This study will determine the effectiveness of adding a parent-involved intervention to cognitive behavior therapy in reducing depressive symptoms among Latino adolescents with depression. Ages 13-17. Location in San Juan, Puerto Rico.
- Dopamine Receptor Imaging in Mood Disorders.
Evaluation study. This study seeks to increase the understanding of dopamine receptor function in the brain during major depressive disorder and bipolar depression, as well as genetic changes that may be behind changes in those receptors' actions. Ages 18-55. Location in Bethesda, MD.
- Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression.
Interventional study. This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns. Ages 12-50. Location in Dallas, TX.
- Hormonal Causes of Menstrual-Related Mood Disorders.
Evaluation study. This study will explore possible hormonal causes of menstrual-related mood disorders (MRMD) by stopping the menstrual cycle with a drug called Lupron and then giving in sequence two menstrual cycle hormones, progesterone and estrogen. Ages 18-45. Location in Bethesda, MD.
- Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders.
Evaluation study. This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression. Ages 18-50. Location in Bethesda, MD.
- Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression.
Interventional study. This study will determine the effectiveness of adding S-adenosyl methionine to antidepressant drug treatment in reducing depressive symptoms in depressed people who have not responded to antidepressants alone. Ages 18-80. Location in Boston, MA.
- Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives.
Interventional study. This study will determine whether uninterrupted treatment with birth control pills over several menstrual cycles prevents severe premenstrual syndrome (PMDD). Location in Bethesda, MD.
- Rapid Antidepressant Effects of Ketamine in Major Depression.
Interventional study. This study examines whether Ketamine can cause a rapid-next day antidepressant effect in patients with Major Depression/Bipolar Disorder . Ages 18-65. Location in Bethesda, MD.
- Lexapro and Pramipexole and to Treat Major Depression.
Interventional study. This study compares the effectiveness of the combination of antidepressants: Lexapro and Pramipexole, with the effectiveness of each antidepressant alone. Ages 18-65. Location in Bethesda, MD.
- Function of Catecholamines in the Brain During Depression.
Evaluation study. This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain neurotransmitter catecholamine. Ages 18-45. Location in Bethesda, MD.
- Dutasteride to Treat Women With Menstrually Related Mood Disorders.
Interventional study. This study will explore the effects of dutasteride on mood and the stress response across the menstrual cycle. Ages 30-45. Location in Bethesda, MD.
- Rapid Antidepressant Effects of Yohimbine in Major Depression.
Interventional study. This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours. Ages 18-65. Location in Bethesda, MD.
- Medication Treatment for Depression in Nursing Home Residents.
Interventional study. This study will examine therapeutic and adverse effects of continuing versus discontinuing antidepressant medication in nursing home residents who have had no more than a single episode of depression and who no longer have depressive symptoms. Ages 65 and over. Location in Philadelphia, PA.
- Reducing Symptoms of Depression in Low-Income Mothers.
Interventional study. This study will test the effectiveness of a short-term intervention in treating depressed young mothers with young children enrolled in Early Head Start Programs. Ages 15 and over. Locations in Asheville, NC; Chapel Hill, NC; Goldsboro, NC; Greensboro, NC; Syracuse, NY.
- Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder.
Evaluation study. This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers. Ages 18-50. Location in Bethesda, MD.
- The Effects of Estrogen Withdrawal on Mood Symptoms in Women.
Evaluation study. This study evaluates the effects on mood when stopping estrogen replacement therapy. Ages 45-65. Location in Bethesda, MD.
- Brain Regulation of Emotions in People With Depression and Anhedonia.
Evaluation study. This study will use magnetic resonance imaging (MRI) to examine how the brain regulates emotions in healthy people and in patients who have major depression and anhedonia (loss of feeling of pleasure in things that normally give pleasure). Ages 18-50. Location in Bethesda, MD.
- Clinical Trial of Estrogen for Postpartum Depression.
Interventional study. This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.
- Screening Evaluation for Women With Postpartum Depression.
Evaluation study. This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.
- Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies.
Interventional study. This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging. Ages 18-45. Location in Bethesda, MD.
- Brain Imaging in Depression.
Evaluation study. The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. Ages 18-45. Location in Bethesda, MD.
- MRI Study of Brain Activity and Risk for Depression in Adolescents.
Evaluation study. Anxiety in children of parents with major depressive disorder (MDD) poses a particularly high risk for later-life MDD. Ages 10-55. Locations in Bethesda, MD; New York, NY; Providence, RI.
- Raloxifene and Rimostil for Perimenopause-Related Depression.
Interventional study. The purpose of this study is to evaluate the effectiveness of the drugs raloxifene and rimostil in treating perimenopause-related depression. Ages 40-60. Location in Bethesda, MD.
- Examination of Brain Serotonin Receptors in Patients With Mood Disorders.
Evaluation study. The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. Ages 18-60. Location in Bethesda, MD.
- Brain Function in Mentally Ill Adolescents.
Evaluation study. The purpose of this study is to use brain imaging technology to examine the brain activity of adolescents with post-traumatic stress disorder (PTSD) and/or major depressive disorder (MDD) before and after treatment. Ages 7-18. Locations in Newark, DE; Bethesda, MD.
- Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes.
Evaluation study. This study uses functional magnetic resonance imaging (fMRI) to learn how the brain functions in adolescents receiving fluoxetine (Prozac) cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) for anxiety or depression in children/adolescents. Ages 8-40. Locations in Bethesda, MD; New York, NY.
- Combined Hormone Replacement in Menstrually-Related Mood Disorders.
Interventional study. This study investigates the effects on symptoms of combined treatment with estrogen and progesterone in women with severe premenstrual syndrome (PMDD). Ages 18-50. Location in Bethesda, MD.
- Evaluation of the Genetics of Bipolar Disorder.
Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Locations in La Jolla, CA; Orange, CA; Washington, DC; Iowa City, IA; Chicago, IL; Indianapolis, IN; Louisville, KY; Baltimore, MD; Detroit, MI; St. Louis, MO; Stonybrook, NY; Philadelphia, PA.
- Study of Premenstrual Syndrome and Premenstrual Dysphoria.
Evaluation study. The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS). Ages 18-50. Location in Bethesda, MD.
- Perimenopause-Related Mood and Behavioral Disorders.
Evaluation study. The purpose of this study is to investigate mood and behavior changes in the time period surrounding and including menopause. Ages 40-60. Location in Bethesda, MD.
- A Treatment Study for Premenstrual Syndrome (PMS).
Interventional study. This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome. Ages 20-45. Location in Bethesda, MD.
- Brain Tissue Collection for Neuropathological Studies.
Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
- The Role of Hormones in Postpartum Mood Disorders.
Evaluation study. Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. Ages 18-40. Location in Bethesda, MD.
Search ClinicalTrials.gov for other NIH studies on Depression.
