The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids - Full Text View

Sponsors and Collaborators:	Radboud University ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:	Radboud University
ClinicalTrials.gov Identifier:	NCT00184899

Purpose

The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation.

The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.

Condition	Intervention
Obesity Metabolic Syndrome X	Drug: Intravenous infusion of Intralipid/heparin Drug: Intravenous infusion of Glycerol/heparin

MedlinePlus related topics: Blood Thinners Metabolic Syndrome Obesity

Drug Information available for: Heparin Glycerol Adenosine

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Educational/Counseling/Training, Randomized, Single Blind, Placebo Control, Crossover Assignment, Pharmacodynamics Study
Official Title:	The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids

Further study details as provided by Radboud University:

Primary Outcome Measures:

Forearm blood flow
Vasoactive effect of caffeine
Sympathetic activity (noradrenaline spillover, spectral analysis)

Estimated Enrollment:	20
Study Start Date:	August 2005
Estimated Study Completion Date:	August 2006

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy volunteers

Exclusion Criteria:

Pregnancy
Asthma
Use of medication
Cardiovascular/pulmonary disease and diabetes

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00184899

Locations

Netherlands
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500HB

Sponsors and Collaborators

Radboud University

ZonMw: The Netherlands Organisation for Health Research and Development

Investigators

Principal Investigator:

Paul Smits, MD, PhD

Radboud University

More Information

Publications:

Bakker SJ, Gans RO, ter Maaten JC, Teerlink T, Westerhoff HV, Heine RJ. The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis. 2001 Apr;155(2):283-90.

Study ID Numbers:	Intralipid-Ado, ZonMw Nr. 920-03-249
Study First Received:	September 12, 2005
Last Updated:	February 28, 2007
ClinicalTrials.gov Identifier:	NCT00184899
Health Authority:	Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Radboud University:

free fatty acids
vasodilation
sympathetic activity

Study placed in the following topic categories:

Obesity
Metabolic Syndrome X
Metabolic Diseases
Overweight
Calcium heparin
Body Weight
Signs and Symptoms
Hyperinsulinism
Glycerol

Syndrome X
Nutrition Disorders
Overnutrition
Insulin Resistance
Metabolic disorder
Glucose Metabolism Disorders
Adenosine
Heparin
Abdominal obesity metabolic syndrome

Additional relevant MeSH terms:

Fibrin Modulating Agents
Anticoagulants
Pathologic Processes
Disease
Molecular Mechanisms of Pharmacological Action
Therapeutic Uses

Syndrome
Hematologic Agents
Fibrinolytic Agents
Cardiovascular Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 14, 2009