NKDEP has developed specific creatinine
standardization recommendations for each group that plays a critical
role in the implementation of creatinine standardization worldwide. The
recommendations outline the steps necessary to ensure a smooth
transition from traditional calibration of routine creatinine methods
to calibration that is traceable to an isotope dilution mass
spectrometry reference method. The following creatinine standardization
recommendations update those originally published in Clinical Chemistry 2006;52(1):5-18. Updated recommendations exist for:
Background
The Creatinine Standardization Program was created by NKDEP’s
Laboratory Working Group in collaboration with the International
Federation of Clinical Chemistry and Laboratory Medicine and the
European Communities Confederation of Clinical Chemistry to reduce
interlaboratory variation in creatinine assay calibration and enable
more accurate estimates of glomerular filtration rate. The effort is
part of a larger NKDEP initiative to help providers better identify and
treat chronic kidney disease in order to prevent or delay kidney
failure and improve patient outcomes.
Contact Information
For questions about the recommendations, please contact us.
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