Unit on Clinical Investigation

Head: Lynnette K. Nieman

Over the past decade, our group has made important contributions to the differential diagnosis of hypercortisolism. We established the corticotropin-releasing hormone (CRH) test and inferior petrosal sinus sampling (IPSS) as major diagnostic tools in the identification of pituitary adenomas causing Cushing’s syndrome. However, the detection of Cushing’s syndrome remains difficult, as does localization of ectopic ACTH-producing tumors (Newell-Price et al., Lancet 2006;3;367:1605). We also evaluate the pathophysiology of and potential new treatments for fibroids in women. This reproductive disorder is common, poorly understood, and lacks optimal medical treatments.

Resources

• Employee Listing
• E-Mail the Lab: niemanl@mail.nih.gov