| Agent Name |
2-Ethoxyethanol |
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| Alternative Name |
Ethylene glycol monoethyl ether |
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| CAS Number |
110-80-5 |
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| Formula |
C4-H10-O2 |
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| Major Category |
Solvents |
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| Synonyms |
2-Ethoxyethanol; 2-Ethoxyethyl alcohol; Bikanol E 1; Cellosolve; Cellosolve solvent;
Dowanol 8; Dowanol EE; EGEE; Ektasolve EE; Emkanol; Ethanol, 2-ethoxy-; Ethyl cellosolve; Ethyl ethylene glycol; Ethylene glycol ethyl ether; Ethylene glycol monoethyl ether; Ethylethylene glycol; Glycol monoethyl ether; Hydroxy ether; Jeffersol EE; Oxitol; Plastiazan 60; Poly-Solv EE; RCRA waste number U359; Solvid; Solvulose; beta-Ethoxyethanol; [ChemIDplus] UN1171
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| Category |
Glycol Ethers |
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| Description |
Colorless liquid with a sweet, pleasant, ether-like odor; [NIOSH] |
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| Sources/Uses |
Used as an industrial solvent and anti-icing additive to aviation fuels; [ACGIH] Used as a solvent for coatings, inks, adhesives, textile dyes, lacquers, and epoxy resins; [HSDB] |
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| Comments |
Changes in the lungs, kidneys, liver, and spleen are seen in mice after 7-hour lethal concentration studies. For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See "Glycol ethers." |
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| Exposure Assessment |
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| BEI |
2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek; |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
5 ppm |
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| PEL (OSHA) |
200 ppm |
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| MAK |
2 ppm |
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| IDLH (NIOSH) |
500 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: Some investigators have stated that at ordinary room temperatures substantially saturated atmospheres (i.e., about 6,000 ppm) will not produce serious injury in 1 hour [Waite et al. 1930].
Human data: Volunteers with some work experience reported that odor levels of 125 ppm were noticeable and that the odor level that would be intolerable was greater than 255 ppm [Clayton and Clayton 1982]. |
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| Vapor Pressure |
5.31 mm Hg |
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| Odor Threshold Low |
0.3 ppm |
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| Odor Threshold High |
24 ppm |
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| Lethal Concentration |
LC50 (rats) = 2,000 ppm/7 hr |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 2.7 ppm); Flash point = 43 deg C; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ETHYLENE GLYCOL MONOETHYL ETHER
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