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Abstract

Title: Management of women who have a genetic predisposition for breast cancer.
Author: Jatoi I,Anderson WF
Journal: Surg Clin North Am 88(4):845-viii
Year: 2008
Month: August

Abstract: The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian cancer. Screening, prophlyactic surgery, and chemoprevention are commonly utilized strategies in the management of these patients, and women may choose more than one of these strategies. No randomized prospective trials have assessed the impact of these strategies specifically in mutation carriers. All patients should be informed that screening, prophylactic surgery, and chemoprevention have the potential for harm as well as benefit.