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Abstract

Title: On the power of affected relative pair designs for linkage studies.
Author: Li Z, Gastwirth JL
Journal: Ann Hum Genet 68(Pt 1):65-68
Year: 2004
Month: January

Abstract: Using the recurrence risk ratio (lambda), Risch (1990b) indicated that affected pairs of distant relatives are preferable to affected sib-pairs for linkage analysis when lambda is large and the mode of inheritance is additive. By using the optimum test for affected sib-pairs instead of the test used by Risch (1990b), the range of values of lambda for which the affected sib-pair design has larger or smaller power than other pairs is clarified. Risch's conclusion remains true when lambdaO > 2.5, however, sib-pairs have larger power for lower values. As affected sib-pairs occur smore frequently than other relative pairs, when ascertainment costs are non-negligible, they may be the most cost-effective relative pairs to use.