The primary emphasis of the general Genetics and Genomics Program is on studies that develop genomics and genetics tools for humans and model organisms, including the non-mammalian model organisms such as zebrafish, Drosophila, C. elegans, Xenopus and yeast. Relevant studies include development of
- Statistical techniques for mapping quantitative trait loci (QTLs) or genes contributing to complex traits, including haplotype mapping of kidney, urologic, or hematologic traits
- Microarray and other high-throughput genomics and proteomics technologies
- Genomic analysis of humans, zebrafish, and other model organisms
- Development of genomics tools for creation of transgenic or knockout animals
- Genome-anatomy projects focusing on renal or urologic tissues or progenitor cells.
Renal Genetics and Genomics
The primary emphasis of the Renal Genetics and Genomics Program is on studies that use genomics and genetics approaches to elucidate the normal and pathologic function of the kidney, including the renal consequences of diseases such as diabetes, hypertension, and ischemia, kidney development and growth, and cyst formation in the kidney. Relevant studies include
- Genetics studies of normal kidney development or kidney disease, such the elucidation of the inheritability or molecular genetic basis of single-gene or genetically complex familial diseases in humans
- Identification and characterization of quantitative trait loci or of modifier loci affecting single gene traits in humans or animal models
- Mutagenesis and mutant screens in model organisms
- Genotype-phenotype correlations in humans and animal models In addition, the program includes
- Genomics- and proteomics-based nephrology studies, such as novel tools for tissue-specific gene expression or site-directed mutagenesis in animal models
- Microarray-based genotyping or expression studies
- High-throughput characterization of tissue-specific gene or protein expression patterns
- High-throughput characterization of tissue-specific protein-protein interactions
Urology Genetics and Genomics
The primary emphasis of the Urology Genetics and Genomics Program is on studies that use genomics and genetics approaches to elucidate the normal and pathologic function of the urinary and urogenital tracts. Relevant studies include
- Urology genetics studies, such the elucidation of the inheritability or molecular genetic basis of single-gene or genetically complex familial diseases in humans
- Identification and characterization of quantitative trait loci or of modifier loci affecting single-gene traits in humans or animal models
- Mutagenesis and mutant screens in model organisms
- Genotype-phenotype correlations in humans and animal models
In addition, the program includes genomics- and proteomics-based urology studies, such as
- Development of novel tools for tissue-specific gene expression or site-directed mutagenesis in animal models
- Microarray-based genotyping or expression studies
- High-throughput characterization of tissue-specific gene or protein expression patterns
- High-throughput characterization of tissue-specific protein-protein interactions
For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.
