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Our Science – Hearing Website

Vincent J. Hearing, Ph.D.

Selected Publications
1)  Ando H, Kondoh H, Ichihashi M, Hearing VJ.
Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase.
J. Invest. Dermatol. 127: 751-61, 2007. [Journal]
2)  Costin GE, Hearing VJ.
Human skin pigmentation: melanocytes modulate skin color in response to stress.
FASEB J. 21: 976-94, 2007. [Journal]
3)  Hearing VJ.
Regulating melanosome transfer: who's driving the bus?.
Pigment Cell Res. 20: 334-5, 2007. [Journal]
4)  Hu ZZ, Valencia JC, Huang H, Chi A, Shabanowitz J, Hearing VJ, Appella E, Wu C.
Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes.
Int J Mass Spectrom. 259: 147-160, 2007. [Journal]
5)  Kobayashi T, Hearing VJ.
Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo.
J. Cell. Sci. 120: 4261-8, 2007. [Journal]
6)  Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Zmudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ, Hearing VJ.
Regulation of human skin pigmentation and responses to ultraviolet radiation.
Pigment Cell Res. 20: 2-13, 2007. [Journal]
7)  Passeron T, Coelho SG, Miyamura Y, Takahashi K, Hearing VJ.
Immunohistochemistry and in situ hybridization in the study of human skin melanocytes.
Exp. Dermatol. 16: 162-70, 2007. [Journal]
8)  Passeron T, Valencia JC, Bertolotto C, Hoashi T, Le Pape E, Takahashi K, Ballotti R, Hearing VJ.
SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation.
Proc Natl Acad Sci U S A. 104: 13984-9, 2007. [Journal]
9)  Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Jenkins LM, Nagashima K, Appella E, Hearing VJ.
Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils.
J. Biol. Chem. 282: 11266-80, 2007. [Journal]
10)  Yamaguchi Y, Brenner M, Hearing VJ.
The regulation of skin pigmentation.
J Biol Chem. 282: 27557-61, 2007. [Journal]
11)  Yamaguchi Y, Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T, Hearing VJ.
The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation.
J. Invest. Dermatol. 127: 1217-25, 2007. [Journal]
12)  Beer JZ, Hearing VJ. Giacomoni PU, eds.
Skin color, melanin, race/ethnicity and UV-induced DNA damage. In: Biophysical and Physiological Effects of Solar Radiation in Human Skin. Volume .
Cambridge: Royal Society of Chemistry; 2007. p. 99-126 [Book Chapter]
13)  Brenner M, Coelho SG, Beer JZ, Miller SA, Wolber R, Smuda C, Hearing VJ.
Long-term molecular changes in human skin after repetitive in situ UV irradiation.
J. Invest. Dermatol. 2008. In Press. [Journal]
14)  Brenner M, Hearing VJ.
Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents.
Drug Discovery Today - Disease Mechanisms. 2008. In Press. [Journal]
15)  Brenner M, Hearing VJ.
The protective role of melanin against UV damage in human skin.
Photochem. Photobiol. 84: 539-49, 2008. [Journal]
16)  Choi W, Wolber R, Gerwat W, Mann T, Hearing VJ.
Characterization of the influence of fibroblasts on melanocyte function and pigmentation (XXth Intl Pigment Cell Conference).
Volume . In Press. [Meeting Proceeding]
17)  Coelho SG, Zhou Y, Bushar HF, Miller SA, Beer JZ, Hearing VJ.
Insights into UV-induced long-lasting pigmentation (LLP) in human skin (XXth Intl Pigment Cell Conference).
Volume . In Press. [Meeting Proceeding]
18)  Hearing VJ, Merlino G. Balch CM, Houghton AN, Sober AJ, Soong S, Atkins MB, Thompson JF, eds.
Melanocyte biology and metastasis. In: Cutaneous Melanoma. Volume .
St. Louis: Quality Medical Publ; 2008. In Press. [Book Chapter]
19)  Hearing V, Passeron T, inventor; DHHS, assignee.
Compositions and Methods for Treating Pigmentary Conditions and Melanoma.
Patent Pending, Filed in 2007. Application No. 60/963280. Pending [Patent]
20)  Hearing V, Yamaguchi Y, Passeron T, inventor; DHHS, assignee.
Regulation of Skin Characteristics by Dickkopf 1 (DKK1).
Patent Pending, Filed in 2006. Application No. 60/873874. Pending [Patent]
21)  Le Pape E, Wakamatsu K, Giubellino A, Valencia JC, Passeron T, Ito S, Hearing VJ.
Regulation of melanocyte fate by an inverse agonist of MC1R, agouti signal protein (XXth Intl Pigment Cell Conference).
Volume . In Press. [Meeting Proceeding]
22)  Le Pape E, Wakamatsu K, Ito S, Wolber R, Hearing VJ.
Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor.
Pigment cell & melanoma research. 21: 477-86, 2008. [Journal]
23)  Miller SA, Coelho SG, Zmudzka BZ, Bushar HF, Yamaguchi Y, Hearing VJ, Beer JZ.
Dynamics of pigmentation induction by repeated ultraviolet exposures: dose, dose interval and ultraviolet spectrum dependence.
Br. J. Dermatol. 2008. In Press. [Journal]
24)  Namiki T, Valencia JC, Hall MD, Hearing VJ.
A novel approach to enhance antibody specificity and sensitivity by peptide cross-linking.
Anal. Biochem. 2008. In Press. [Journal]
25)  Namiki T, Valencia JC, Hearing VJ.
Characterization of the localization and function of P and MATP in melanocytes (XXth Intl Pigment Cell Conference).
Volume . In Press. [Meeting Proceeding]
26)  Passeron T, Namiki T, Passeron H, Le Pape E, Hearing VJ.
Forskolin Protects Keratinocytes from UVB-Induced Apoptosis and Increases DNA Repair Independent of its Effects on Melanogenesis.
J. Invest. Dermatol. 2008. In Press. [Journal]
27)  Watabe H, Valencia JC, Le Pape E, Yamaguchi Y, Nakamura M, Rouzaud F, Hoashi T, Kawa Y, Mizoguchi M, Hearing VJ.
Involvement of Dynein and Spectrin with Early Melanosome Transport and Melanosomal Protein Trafficking.
J Invest Dermatol. 128(1): 162-174, 2008. [Journal]
28)  Wolber R, Schlenz K, Wakamatsu K, Smuda C, Nakanishi Y, Hearing VJ, Ito S.
Pigmentation effects of solar-simulated radiation as compared with UVA and UVB radiation.
Pigment cell & melanoma research. 21: 487-91, 2008. [Journal]
29)  Yamaguchi Y, Beer JZ, Hearing VJ.
Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer.
Arch. Dermatol. Res. 300 Suppl 1: S43-50, 2008. [Journal]
30)  Yamaguchi Y, Coelho SG, Zmudzka BZ, Takahashi K, Beer JZ, Hearing VJ, Miller SA.
Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation.
Exp. Dermatol. 2008. In Press. [Journal]
31)  Yamaguchi Y, Passeron T, Hoashi T, Watabe H, Rouzaud F, Yasumoto K, Hara T, Tohyama C, Katayama I, Miki T, Hearing VJ.
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes.
FASEB J. 22: 1009-20, 2008. [Journal]

This page was last updated on 9/10/2008.