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Sponsors and Collaborators: |
Central Institute of Mental Health, Mannheim BMBF – Bundesministerium für Bildung und Forschung |
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Information provided by: | Central Institute of Mental Health, Mannheim |
ClinicalTrials.gov Identifier: | NCT00326742 |
Aim of the project is to validate and functionally characterize the combined impact of candidate genes and stress exposure on drinking in adolescents. Lifetime and recent stress experiences and drinking are recorded in a sample of healthy young adults who are genotyped for polymorphisms in candidate genes related to alcoholism. All participants undergo a standard laboratory psychosocial stress test. Our hypothesis is that specific genes can be identified which influence drinking by modulating stress response.
Condition | Intervention |
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Alcohol Drinking |
Behavioral: Trier Social Stress Test |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study |
Official Title: | Validation in Humans of Genes Involved in Alcohol Drinking, Stress-Induced Alcohol Drinking and Relapse |
Ages Eligible for Study: | 18 Years to 19 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Germany, BW | |
Department of Addictive Behavior und Addiction Medicine, Central Institute of Mental Health | |
Mannheim, BW, Germany, 68159 |
Principal Investigator: | Karl F Mann, Prof | Central Institute of Mental Health, Mannheim |
Study ID Numbers: | NGFN 2 01 GS 0475 |
Study First Received: | May 16, 2006 |
Last Updated: | May 9, 2007 |
ClinicalTrials.gov Identifier: | NCT00326742 |
Health Authority: | Germany: Ethics Commission |
Alcoholism Risk factors Adolescence Stress test HPA system |
Family adversity Candidate genes Cortisol Adrenocorticotrophin |
Hydrocortisone Cortisol succinate Alcoholism Drinking Behavior Stress |
Hydrocortisone acetate Alcohol Drinking Adrenocorticotropic Hormone Ethanol |