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Sponsored by: |
National Institutes of Health Clinical Center (CC) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001840 |
This project will investigate the evolution of treated and untreated stroke in patients recruited from the collaborative brain stroke program between NINDS, CC, and Suburban Hospital. The study will use anatomical and functional imaging techniques with emphasis on the acute and subacute stage (less than one month) of the disease.
As the availability of new therapeutic options for the management of acute brain stroke increases, the need to define the evolution of the disease becomes paramount, particularly as therapeutic windows, defined by known and perhaps yet undiscovered parameters, may exist. Defining these parameters will be based on state-of-the-art imaging technology with the potential of clarifying the division between ischemia (reversible damage) and infarction (irreversible). Measures of lesion size and distribution along with vascular morphology, diffusion, perfusion, flow-related, and metabolic measures will be obtained over time. We foresee these measurements will significantly develop our understanding of cerebral ischemia and introduce diagnostic and quantitative tools to guide therapy and measure its efficacy.
Condition |
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Cerebrovascular Accident Infarction Ischemia |
Study Type: | Observational |
Official Title: | Evaluation of Treated and Untreated Stroke |
Estimated Enrollment: | 100 |
Study Start Date: | February 1999 |
Estimated Study Completion Date: | July 2001 |
This project will investigate the evolution of treated and untreated stroke in patients recruited from the collaborative brain stroke program between NINDS, CC, and Suburban Hospital. The study will use anatomical and functional imaging techniques with emphasis on the acute and subacute stage (less than one month) of the disease.
As the availability of new therapeutic options for the management of acute brain stroke increases, the need to define the evolution of the disease becomes paramount, particularly as therapeutic windows, defined by known and perhaps yet undiscovered parameters, may exist. Defining these parameters will be based on state-of-the-art imaging technology with the potential of clarifying the division between ischemia (reversible damage) and infarction (irreversible). Measures of lesion size and distribution along with vascular morphology, diffusion, perfusion, flow-related, and metabolic measures will be obtained over time. We foresee these measurements will significantly improve our understanding of cerebral ischemia and introduce diagnostic and quantitative tools to guide therapy and measure its efficacy.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Any subject suspected of having a stroke based on the NIH Stroke Scale and age 21 years or over.
Subjects will be enrolled into this protocol only if they are determined intellectually capable of providing their own informed consent.
No subjects will be included if they have a condition which would preclude their entry into the scanner (e.g., paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.) or present unnecessary risks (e.g., surgery of uncertain type, symptoms of pheochromocytoma or insulinoma, etc.).
No women who are pregnant or lactating.
No subjects with hemoglobinopathies and asthma.
No subjects with renal or hepatic disease.
No subjects who have a contraindication to MR scanning such as surgery that involves metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (e.g., aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, cochlear implant, ocular foreign body and mechanical pump).
Study ID Numbers: | 990041, 99-CC-0041 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001840 |
Health Authority: | United States: Federal Government |
Infarct Ischemia MRI Natural History |
Stroke Treatment Brain Stroke |
Necrosis Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases Brain Ischemia |
Brain Infarction Ischemia Brain Diseases Infarction Cerebrovascular Disorders |
Pathologic Processes Nervous System Diseases Cardiovascular Diseases |