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| Sponsored by: |
National Cancer Institute (NCI) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00001805 |
Purpose
This is a phase II clinical and pharmacokinetic study of suppression of human antimouse (HAMA) and antitoxin antibodies (HATA) to immunotoxin LMB-1 by Rituximab (anti-CD20). The primary objective of this study is to determine the effect of Rituximab on HAMA and HATA response to LMB-1 administered to patients with advanced carcinoma that express the B3 antigen. Other objectives include evaluation of the pharmacokinetics and anti-tumor effects.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Neoplasms Colonic Neoplasms Lung Neoplasms Pancreatic Neoplasms Stomach Neoplasms |
Drug: Rituximab |
Phase II |
| Study Type: | Interventional |
| Study Design: | Treatment, Safety/Efficacy Study |
| Official Title: | A Phase II Clinical Trial of Suppression of Human Antimouse Antibody and Human Antitoxin Response to Immunotoxin LMB-1 by Rituximab |
| Estimated Enrollment: | 20 |
| Study Start Date: | March 1999 |
| Estimated Study Completion Date: | June 2000 |
This is a phase II clinical and pharmacokinetic study of suppression of human antimouse (HAMA) and antitoxin antibodies (HATA) to immunotoxin LMB-1 by Rituximab (anti-CD20). The primary objective of this study is to determine the effect of Rituximab on HAMA and HATA response to LMB-1 administered to patients with advanced carcinoma that express the B3 antigen. Other objectives include evaluation of the pharmacokinetics and anti-tumor effects.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Patients must have advanced stage solid tumor with histologically or cytologically proven evaluable or measurable disease and who are refractory to standard treatment for their malignancy or for whom no effective standard therapy exists.
Must have the presence of B3 antigen on the surface of greater than 30% of the tumor cells.
Must be greater than or equal to 18 years old and be able to give informed consent.
Must have an ECOG performance status of 0 or 1 and a minimum life expectancy of 3 months.
Must have normal renal function (Creatinine less than or equal to 1.4 mg/dl), SGOT and SGPT less than or equal to 2.5 x of the upper limits of normal. Total bilirubin less than 1.5 mg/dL; AGC greater than or equal to 1.5 x 10(3) microliter; platelets greater than 100,000 per mm(3).
Must have recovered from the toxic effects of prior chemotherapy or radiation therapy. At least 3 weeks must have elapsed since the last dose of chemotherapy, hormonal therapy or radiation therapy. At least six weeks must have elapsed since the last dose of Mitomycin C and a nitrosourea.
Must not have serum neutralizing antibodies to LMB-1.
Must not have positive hepatitis B surface antigen, hepatitis C antibody or HIV.
Must not have a history of coronary artery disease, NY class II-IV CHF, arrhythmia requiring treatment and any contraindication to pressor therapy.
Must not have FEV1 and FVC less than or equal to 65% of the predicted value.
Must not have baseline serum albumin of less than 3.0 g/dl.
Must not have a history of CNS metastasis and/or known seizure disorders, or concurrent malignancy.
Must not have an acute bacterial infection that requires antibiotic therapy (unless infection is completely resolved).
Must not have any coexisting medical or psychiatric condition that is likely to interfere with study procedures and/or results.
Must not be pregnant or breastfeeding. Patients of childbearing potential must agree to use an effective method of contraception.
Must not have a history of allergic reaction to penicillin.
Must not have lymphoma.
Contacts and Locations More Information
| Study ID Numbers: | 990071, 99-C-0071 |
| Study First Received: | November 3, 1999 |
| Last Updated: | March 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00001805 |
| Health Authority: | United States: Federal Government |
|
Breast Cancer Colon Cancer Gastric Cancer Lung Cancer Pancreatic Cancer |
|
Thoracic Neoplasms Gastrointestinal Diseases Pancreatic Neoplasms Colonic Diseases Stomach Diseases Respiratory Tract Diseases Lung Neoplasms Stomach Neoplasms Breast Diseases Immunoglobulins Endocrine Gland Neoplasms Antitoxins Digestive System Neoplasms Skin Diseases Rituximab |
Breast Neoplasms Endocrine System Diseases Stomach cancer Intestinal Diseases Immunotoxins Intestinal Neoplasms Antibodies Digestive System Diseases Lung Diseases Gastrointestinal Neoplasms Pancreatic Diseases Endocrinopathy Colonic Neoplasms Colorectal Neoplasms |
|
Respiratory Tract Neoplasms Neoplasms Neoplasms by Site Immunologic Factors Antineoplastic Agents |
Therapeutic Uses Physiological Effects of Drugs Antirheumatic Agents Pharmacologic Actions |
