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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001489 |
This study is designed to test the effects of vigabatrin (gamma-vinyl-GABA) an experimental drug used for the treatment of epilepsy. The study will use positron emission tomography (PET scan) to detect areas of the brain receiving increased blood flow and using increased amounts of glucose. Increases in blood flow and glucose use are good indicators of brain activity.
Researchers are interested in determining the effects of Vigabatrin on brain blood flow and glucose use.
Condition |
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Epilepsy Epilepsy, Complex Partial |
Study Type: | Observational |
Official Title: | The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism |
Estimated Enrollment: | 20 |
Study Start Date: | October 1994 |
Estimated Study Completion Date: | August 2000 |
This double-blind placebo-controlled parallel design protocol will investigate the effects of gamma-vinyl-GABA (vigabatrin--GVG) an experimental antiepileptic drug, on cerebral glucose metabolism (LCMRglc), blood flow (CBF), and seizure frequency, in patients with uncontrolled complex partial (CPS) and secondary generalized seizures (GTCS). Positron Emission Tomography (PET) will be used to measure CBF and LCMRglc.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Localization-related epilepsy.
Uncontrolled seizures.
Ability to tolerate tegretol monotherapy.
No systemic illness requiring drug therapy.
No illness that might be made worse by vigabatrin.
Study ID Numbers: | 950008, 95-N-0008 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001489 |
Health Authority: | United States: Federal Government |
Cerebral Metabolism Complex Partial Seizures Epilepsy |
Epilepsies, Partial Epilepsy, Complex Partial Vigabatrin Epilepsy |
Seizures Central Nervous System Diseases Brain Diseases |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Therapeutic Uses Physiological Effects of Drugs Nervous System Diseases |
GABA Agents Enzyme Inhibitors Central Nervous System Agents Anticonvulsants Pharmacologic Actions |