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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001176 |
Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.
Previous studies conducted on patients with salt sensitive hypertension suggest that their portion of the nervous system responsible for maintaining normal blood pressure (autonomic nervous system) may respond differently to salt than patients with non-salt sensitive (NSS) hypertension.
This study is designed to examine the response of the nervous system to high doses of salt in patients with salt-sensitive hypertension and patients with non-salt sensitive hypertension.
Condition |
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Hyperaldosteronism Hypertension |
Study Type: | Observational |
Official Title: | The Function of Dopaminergic and Noradrenergic Systems in Salt-Sensitive Hypertension: The Effects of Changes in Sodium Intake |
Estimated Enrollment: | 110 |
Study Start Date: | May 1981 |
Estimated Study Completion Date: | December 2001 |
A subset of patients with idiopathic hypertension shows an increase in blood pressure of 10 percent or more in response to salt-loading and have been termed "salt-sensitive" (SS). Limited studies of adrenergic function in response to salt-loading suggest that the response of SS patients may differ from that of non-salt sensitive (NSS) patients. The present studies were designed to examine the response of the adrenergic and dopaminergic systems to salt-loading in SS and NSS patients with idiopathic hypertension.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Eligibility criteria not identified in protocol.
Study ID Numbers: | 810081, 81-H-0081 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001176 |
Health Authority: | United States: Federal Government |
Adrenergic Nervous System Dopaminergic Nervous System Salt-Sensitive Hypertension Hypertension Primary Aldosteronism |
Dopamine Vascular Diseases Endocrine System Diseases Adrenal Gland Diseases Endocrinopathy |
Conn's syndrome Adrenocortical Hyperfunction Hyperaldosteronism Primary aldosteronism Hypertension |
Cardiovascular Diseases |