Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1

This study has been completed.

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) Johns Hopkins University
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000315

Purpose

The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use. This aim will test the hypothesis that DA transporters are altered by cocaine abuse and reestablished during withdrawal.

Condition	Intervention	Phase
Cocaine-Related Disorders	Drug: Cocaine	Phase I

Drug Information available for: Dopamine Dopamine hydrochloride 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))- Cocaine hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment
Official Title:	Human Dopamine Transported Imaging in Cocaine Abuse: 1

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:

Physiological changes in: heart rate and blood pressure
Subjective effects of cocaine inducements and withdrawal
Psychological effects
Effects of investigational drug

Estimated Enrollment:	0
Study Start Date:	November 1996
Estimated Study Completion Date:	December 2001

Eligibility

Ages Eligible for Study:	21 Years to 45 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000315

Locations

United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21287

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

Johns Hopkins University

Investigators

Principal Investigator:

Dean Wong, M.D., Ph.D.

Johns Hopkins University

More Information

Study ID Numbers:	NIDA-09482-1, R01-09482-1
Study First Received:	September 20, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00000315
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Cocaine-Related Disorders
Dopamine
Mental Disorders

Substance-Related Disorders
Disorders of Environmental Origin
Cocaine

Additional relevant MeSH terms:

Dopamine Uptake Inhibitors
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Anesthetics
Central Nervous System Depressants
Cardiovascular Agents

Pharmacologic Actions
Anesthetics, Local
Sensory System Agents
Therapeutic Uses
Vasoconstrictor Agents
Dopamine Agents
Peripheral Nervous System Agents
Central Nervous System Agents

ClinicalTrials.gov processed this record on January 15, 2009