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Information for Scientific Collaborators
Cancer incidence and mortality data on the cohort are being obtained from cancer registries within Iowa and North Carolina and state vital statistics offices on a yearly basis. In addition, mortality data on the cohort is being obtained every other year from the National Death Index (NDI). Cancer incidence in the cohort is presented in Table 2 and mortality in the cohort is presented in Tables 3.
Table 2a: Post-enrollment (Incident only) Malignant Cancer
Cases by Site and Phase II Data Collection progress 1,2,3
|
Incident Cases Only |
Cancer
Site |
Total with
Cancer |
Completed
Phase II |
Returned Buccal
Sample |
Returned
DHQ |
Bladder |
237 |
144 |
103 |
98 |
Brain |
75 |
27 |
18 |
19 |
Breast |
747 |
577 |
404 |
424 |
Bronchus and Lung |
593 |
276 |
147 |
157 |
Colon |
515 |
321 |
209 |
200 |
Head and Neck |
58 |
27 |
17 |
14 |
Kidney and Renal Pelvis |
187 |
103 |
71 |
68 |
Leukemia |
174 |
93 |
64 |
56 |
Liver and Intrahepatic Bile Ducts |
47 |
18 |
8 |
11 |
Melanoma |
270 |
187 |
122 |
126 |
Mesothelioma |
14 |
4 |
3 |
1 |
Multiple Myeloma |
92 |
58 |
38 |
42 |
NHL |
281 |
169 |
112 |
118 |
Oral |
110 |
77 |
53 |
51 |
Other |
465 |
264 |
163 |
168 |
Ovary |
73 |
54 |
31 |
33 |
Pancreas |
114 |
55 |
23 |
29 |
Prostate |
1,658 |
1,127 |
1,068 |
742 |
Rectum and Rectosigmoid Junction |
207 |
130 |
83 |
87 |
Stomach |
79 |
47 |
37 |
34 |
Thyroid Gland |
94 |
61 |
42 |
40 |
Uterine |
168 |
121 |
78 |
84 |
Total |
6,258 |
3,940 |
2,894 |
2,602 |
Table 2b: Pre- and Post-enrollment (Prevalent and Incident)
Malignant Cancer Cases by Site and Phase II Data Collection progress
1,2,3
|
Prevalent Plus Incident Cases |
Cancer
Site |
Total with
Cancer |
Completed
Phase II |
Returned Buccal
Sample |
Returned
DHQ |
Bladder | 319 |
191 |
134 |
125 |
Brain |
94 |
39 |
25 |
26 |
Breast |
1,202 |
919 |
636 |
676 |
Bronchus and Lung |
638 |
293 |
157 |
169 |
Colon | 658 |
405 |
274 |
258 |
Head and Neck |
76 |
37 |
24 |
21 |
Kidney and Renal Pelvis |
226 |
127 |
87 |
81 |
Leukemia |
229 |
125 |
85 |
80 |
Liver and Intrahepatic Bile Ducts | 49 |
19 |
9 |
12 |
Melanoma |
397 |
275 |
177 |
187 |
Mesothelioma |
14 |
4 |
3 |
1 |
Multiple Myeloma |
103 |
62 |
42 |
45 |
NHL |
384 |
225 |
152 |
164 |
Oral |
166 |
114 |
78 |
78 |
Other |
634 |
373 |
230 |
239 |
Ovary |
122 |
90 |
59 |
59 |
Pancreas |
125 |
58 |
23 |
30 |
Prostate |
2,085 |
1,393 |
1,234 |
938 |
Rectum and Rectosigmoid Junction |
292 |
181 |
123 |
125 |
Stomach |
86 |
49 |
38 |
35 |
Thyroid Gland |
189 |
136 |
94 |
92 |
Uterine |
260 |
189 |
117 |
132 |
Total |
8,348 |
5,304 |
3,801 |
3,573 |
1 Cancer counts are based on nearly complete registry data through 2005.
2 Subjects previously diagnosed with cancer at a different site are included.
3 Buccal cell receipts represent progress through 2007.
4 The 'Other' category includes in-situ bladder cancers.
5 SEER Site Recode ICD-O-3 (1/27/2003) Definition used for classifying cancers.
Table 3: Cause Specific Mortality of AHS Cohort, 1994-2007
Cause |
Frequency |
Percent |
Cumulative
Frequency |
Cumulative
Percent |
Accidents |
370 |
6.50 |
370 |
6.50 |
Cancer |
2,050 |
36.00 |
2.420 |
42.49 |
Cerebrovascular Disease |
295 |
5.18 |
2,715 |
47.67 |
Diabetes Mellitus |
124 |
2.18 |
2,839 |
49.85 |
Heart Disease |
1,613 |
28.32 |
4,452 |
78.17 |
Respiratory Disease |
363 |
6.37 |
4,815 |
84.55 |
Other |
880 |
15.45 |
5,695 |
100.00 |
Table 4: Medical Conditions 1
(fully expanded)
|
Private Applicators |
Spouses |
Commercial Applicators |
Total |
Number in Cohort: |
N=52,395 |
N=32,347 |
N=4,916 |
N=89,658 |
Category |
Count |
Count |
Count |
|
Completed Phase II Questionnaire |
33,457 |
23,796 |
2,885 |
60,138 |
Cardiovascular Disease
Heart Attack (Myocardial Infarction) |
1,789 |
370 |
122 |
2,281 |
Irregular Heart Beat (Arrhythmia) |
3,267 |
2,571 |
243 |
6,081 |
High Blood Pressure or Hypertension |
8,637 |
5,954 |
870 |
15,461 |
|
Endocrine Disorder
Diabetes or High Blood Sugar |
2,429 |
1,314 |
188 |
3,931 |
Thyroid Disease or Thyroid Problems |
1,075 |
2,947 |
90 |
4,112 |
Overactive Thyroid (Hyperthyroidism) |
279 |
659 |
N/A 4 |
N/A |
Graves Disease |
62 |
151 |
N/A 4 |
N/A |
Underactive Thyroid (Hypothyroidism) |
528 |
1,792 |
55 |
2,375 |
Thyroiditis, Hashimoto's Disease, Autoimmune
Disease |
31 |
212 |
N/A 4 |
N/A |
Enlarged Thyroid, Thyroid Nodules, Goiter |
204 |
997 |
N/A 4 |
N/A |
Other Thyroid Problem |
113 |
169 |
N/A 4 |
N/A |
|
Women's Health Disorder
Endometriosis |
N/A 2 |
1,694 |
N/A 2 |
N/A |
Uterine Fibroids |
N/A 2 |
3,514 |
N/A 2 |
N/A |
Benign Breast Disease (Fibroids, Cysts, Other) |
N/A 2 |
4,060 |
N/A 2 |
N/A |
Pregnancy Induced High Blood Pressure,
Pre-Eclampsia, Toxemia or Eclampsia |
N/A 2 |
103 |
N/A 2 |
N/A |
Gestational Diabetes |
N/A 2 |
77 |
N/A 2 |
N/A |
|
Autoimmune/Musculoskeletal Disorders
Rheumotoid Arthritis |
N/A 2 |
908 |
N/A 2 |
N/A |
Lupus (SLE) |
N/A 2 |
110 |
N/A 2 |
N/A |
Sjogren's Disease |
N/A 2 |
43 |
N/A 2 |
N/A |
Scleroderma or Systemic Sclerosis |
N/A 2 |
32 |
N/A 2 |
N/A |
|
Kidney Disorder
Kidney Stones |
3,862 |
1,279 |
200 |
5,341 |
Kidney Disease or Kidney Failure |
354 |
214 |
28 |
596 |
|
Digestive Disorder
Inflammatory Bowel Disease
(Chron's Disease, Ulcerative Colitis) |
430 |
514 |
41 |
985 |
|
Skin Disorder
Vitiligo |
130 |
84 |
N/A 4 |
N/A |
Eczema |
719 |
1,124 |
89 |
1,932 |
Psoriasis |
821 |
582 |
76 |
1,479 |
Allergy to Bees, Wasps, or Other Insects |
1,735 |
1,120 |
158 |
3,013 |
|
Optical or Hearing Disorder
Blindness |
619 |
N/A 3 |
36 |
N/A |
Nearsightedness |
12,237 |
N/A 3 |
1,345 |
N/A |
Farsightedness |
13,683 |
N/A 3 |
1,217 |
N/A |
Cataracts |
3,427 |
N/A 3 |
199 |
N/A |
Glaucoma |
680 |
N/A 3 |
49 |
N/A |
Detached Retina |
358 |
N/A 3 |
30 |
N/A |
Retinal or Macular Degeneration |
391 |
N/A 3 |
34 |
N/A |
Hearing Problems |
11,781 |
N/A 3 |
913 |
N/A |
|
Injury
Head Injury |
6,623 |
1,556 |
726 |
8,905 |
Neck, Back, Spinal Cord Injury |
6,250 |
2,198 |
588 |
9,036 |
Post-Polio Syndrome, Leg Injury |
4,344 |
1,474 |
188 |
6,006 |
|
Neurologic Disorder
Epilepsy |
123 |
127 |
N/A 4 |
N/A |
Multiple Sclerosis |
39 |
83 |
N/A 4 |
N/A |
Parkinson's Disease |
89 |
29 |
N/A 4 |
N/A |
Tremor (Essential, Familial, Benign) |
144 |
113 |
N/A 4 |
N/A |
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1 Numbers represent medical conditions reported during Phase II interviews. Because the asking of some questions was dependent on responses to earlier questions, the counts in this table reflect the numbers of each condition reported but not the total occurrence of the diseases in the cohort.
2 These conditions marked with N/A were not asked about in the men's health questions. Since 96 percent of private applicators and commercial applicators in the cohort are men, it would be misleading to report counts for these conditions in the private applicator column.
3 Hearing problems were not asked about in the women's health questions. Since 99.5 percent of spouses in the cohort are women, it would be misleading to report hearing problem counts in the spouse column.
4 These conditions occur in commercial applicators in insufficient numbers to be reported at this time.
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