9 January, 2009
Volume 136, Issue 1
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Volume 136, Issue 1
On the cover: What factors determine responsiveness to TGFβ and limit the signals so that they reach only the appropriate tissues with the correct intensity? The assembly of the Smad complex is critical for TGFβ signaling. In this issue of Cell, Dupont et al. (pp. 123–135) describe Smad4 monoubiquitination and deubiquitination as a way by which cells shape their responsiveness to TGFβ. This study may provide insight into understanding diseases associated with unrestrained TGFβ signaling. On the cover, how TGFβ signal transduction is shaped by Smad4 ubiquitination is depicted as a canyon that has been shaped over time by the elements. Photo credit: Harry Hu, used with permission under license from 123RF.
Announcements
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Cell Press and TnQ Books & Journals present
India Distinguished Lectureship Series
February 9 - 13, 2009
Hyderabad, Bangalore, and New Delhi
Most Read Papers
- These are the most read by download from the Cell web site for the last 30 days.
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- Cryo-electron microscopy reconstruction of a nucleotide-free kinesin-microtubule complex.
- Crystal structures of the nonmotile kinesin-10 NOD (blue) and tubulin (yellow) were docked into an 11 Å reconstruction. This complex revealed an unexpected clockwise rotation of NOD relative to the microtubule compared to other known kinesin-microtubule complexes. See also paper by Cochran et al., where the authors propose a model for NOD's microtubule plus-end tracking that drives chromosome movement during cell division.
SnapShots
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SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here for a full list of SnapShots. Centriole Biogenesis
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Featured Job
Postdoctoral Positions in Developmental Biology
Postdoctoral positions are available in the Department of Genetics and Tumor Cell Biology to work in different aspects of mammalian organogenesis using available mouse models. Highly motivated individuals who recently obtained a PhD or MD degree and have a strong background in molecular and developmental biology are encouraged to apply. Click here for more information.
In this Issue
- Granulomas as Trojan horse in tuberculosis
- Tying telomerase to the cell cycle
- SIRT6 plugged into the NF-κB pathway
- Self-promoting activities in the Drosha-DGCR8 complex
- Breaking into the inner circle of bacterial condensin
- Assembly and disassembly of an ESCRT
- NODding off at microtubule ends
- The ubiquitous on/off switch for TGFβ signaling
- GPCR and G protein unite in ABA signaling
- Sensationalizing glutamate receptors
- Handing off mitochondrial motility
- PiCh turns ChIP around
- Tying telomerase to the cell cycle
Immediate Early Publication
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
Grzegorz Sumara, Ivan Formentini, Stephan Collins, Izabela Sumara, Renata Windak, Bernd Bodenmiller, Reshma Ramracheya, Dorothée Caille, Huiping Jiang, Kenneth A. Platt, Paolo Meda, Rudolf Aebersold, Patrik Rorsman, and Romeo Ricci
Featured Article
Featured articles are freely available to all readers
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The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection In tuberculosis, aggregates of immune cells known as granulomas have long been thought to act to constrain mycobacterial infection by serving as a cellular barrier to “wall off” the bacteria. Using intravital imaging to study the early events of infection in a zebrafish model for tuberculosis, Davis and Ramakrishnan now provide evidence indicating that the triggering of the innate immune response and the recruitment of macrophages associated with granuloma formation may actually facilitate the expansion of the infection. |
| In this PaperClip, Dr. Fabiola Rivas speaks with Dr. Lalita Ramakrishnan about her group's study showing that granuloma formation promotes mycobacterial expansion and dissemination during the early stages of tuberculosis infection.
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Leading Edge Featured Article
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In this Review, Changchun Xiao and Klaus Rajewsky discuss emerging themes in the regulation of the mammalian immune system by microRNAs.
MicroRNA Control in the Immune System: Basic Principles |
Cell PaperClips
| In this PaperClip, Dr. Angela Andersen speaks with Dr. Tim Nilsen about his group's study which identifies new splice site silencers and provides insight into how alternative splice sites are chosen.
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You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, click here
Cell Podcast
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In our latest podcast, we hear from Dr. Nathaniel Heintz about "TRAP," a new technique reported in Cell for looking at gene expression in the brain. Then we learn about a study in Current Biology from Dr. Robert Fleischer regarding the curious classification of the Hawaiian honeyeater. And we will also hear from Dr. Alan Beggs about his study in the American Journal of Human Genetics presenting a large-scale screen for mutations involved in Diamond-Blackfan anemia.
And stay tuned for a round-up of some of the exciting research advances recently published in Cell and the Cell Press family of journals. |
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