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Juliana H. Aruna--2001, University of Maryland Baltimore County and Patrick M. Barrett-2002, University of Pennsylvania. Mentors: Donald Ingram, Ph.D. and Garrick Li, Ph.D., Behavioral Neuroscience Section, Laboratory of Neurosciences. Lee GD, Aruna JH, Barrett PM, Lei DL, Ingram DK, Mouton PR. Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull. 2005;65(4):317-322.
Tiffani J. Bright--2002, Meyerhoff Scholar, University of Maryland Baltimore County, Master's Program, major-Information Systems. Mentor: Kevin G. Becker, Ph.D., Chief, Gene Expression and Genomics Unit, Research Resources Branch.Becker KG, Hosack DA, Dennis G Jr, Lempicki RA, Bright TJ, Cheadle C, Engel J. PubMatrix: a tool for multiplex literature mining. BMC Bioinformatics. 2003;4(1):61. Becker KG, Barnes KC, Bright TJ, Wang SA. The genetic association database. Nat Genet. 2004;36(5):431-432.
Allyson Bunbury--2002, MARC Program, Brooklyn College, New York. Mentors: Valeria De Mello Coelho, Ph.D. and Dennis Taub, Ph.D, Laboratory of Immunology.De Mello Coelho V, Nguyen D, Giri B, Bunbury A, Schaffer E, Taub DD. Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells. BMC Immunol. 2004;5(1):2.
Jennifer Betkey--1999-2001, Denison University, Granville, Ohio, major-Biology/Chemistry. Mentor: Nigel H. Greig, Ph.D., Chief, Drug Design and Development Section, Laboratory of Neurosciences.Doyle ME, Greig NH, Holloway HW, Betkey JA, Bernier M, Egan JM. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology. 2001;142(10):4462-4468. Hengemihle JM, Long JM, Betkey J, Jucker M, Ingram DK. Age-related psychomotor and spatial learning deficits in 129/SvJ mice. Neurobiol Aging. 1999;20(1):9-18. Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology. 2000;141(6):1936-1941.
Shamika Danzy--2003-2004, Georgia Institute of Technology, Atlanta. Mentors: Patricia Opresko, Ph.D., and Vilhelm A. Bohr, M.D., Ph.D., Laboratory of Molecular Gerontology.Opresko PL, Fan J, Danzy S, Wilson DM III, Bohr VA. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res. 2005;33(4):1230-1239.
Lawrence David--2002-2003, Columbia University School of Engineering, New York. Mentors: Minoru Ko, M.D., Ph.D., Toshiyuki Yoshikawa, M.D., Ph.D. and Ilya Goldberg, Ph.D, Laboratory of Genetics.Glenn CF, Chow DK, David L, Cooke CA, Gami MS, Iser WB, Hanselman KB, Goldberg IG, Wolkow CA. Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol A Biol Sci Med Sci. 2004;59(12):1251-1260.
Saswata Deb--2002, University of Toronto, Ontario. Mentor: Samer Najjar, M.D., Laboratory of Cardiovascular Science. Hougaku H, Fleg JL, Lakatta EG, Scuteri A, Earley CJ, Najjar S, Deb S, Metter EJ. Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening. Am J Cardiol. 2005;95(8):1006-1010.
Salihah A. Dick--2004, MARC Program, Barry University, Florida. Mentors: Kenneth Boheler, Ph.D. and Maria Volkova, Ph.D., Laboratory of Cardiovascular Science. Volkova M, Garg R, Dick S, Boheler KR. Aging-associated changes in cardiac gene expression. Cardiovasc Res. 2005;66(2):194-204.
Scott S. Emerson--2005, University of North Texas Health Science Center, Fort Worth, Texas. Mentors: Dong-Hoon Hyun, Ph.D., Laboratory of Neurosciences, Rafael de Cabo, Ph.D., Laboratory of Experimental Gerontology.Hyun DH, Hunt ND, Emerson SS, Hernandez JO, Mattson MP, Cabo RD. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem. 2007;100(5):1364-1374. Hyun DH, Emerson SS, Jo DG, Mattson MP, de Cabo R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci USA. 2006;103(52):19908-19912.
Jinnifer K. Faulkner--2003, Gettysburg College, Pennsylvania. Mentors: Robert M. Brosh, Ph.D., Sudha Sharma, Ph.D., Laboratory of Molecular Gerontology.Sharma S, Sommers JA, Choudhary S, Faulkner JK, Cui S, Andreoli L, Muzzolini L, Vindigni A, Brosh RM Jr. Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem. 2005;280(30):28072-28084.
Jennifer T. Fox--2002-2003, University of Maryland Baltimore County. Mentors: Vilhelm A. Bohr, M.D., Ph.D., Wen-Hsing Cheng, Ph.D., Laboratory of Molecular Gerontology.Cheng WH, Sakamoto S, Fox JT, Komatsu K, Carney J, Bohr VA. Werner syndrome protein associates with gH2AX in a manner that depends upon Nbs1. FEBS Lett. 2005;579(6):1350-1356.
James J. Gides--2000, St. Francis College, Pennsylvania. Mentor: Audrey N. Kalehua, Ph.D., Laboratory of Immunology.Kalehua AN, Nagel JE, Whelchel LM, Gides JJ, Pyle RS, Smith RJ, Kusiak, JW, Taub DD. Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp Cell Res. 297(1): 197-211, 2004.
Terrance Henderson--1995-1996, Mentor: Josephine M. Egan, M.D., Diabetes Section, Laboratory of Clinical Investigation.Egan JM, Henderson TE, Bernier M. Arginine enhances glycogen synthesis in response to insulin in 3T3-L1 adipocytes. Am J Physiol. 1995;269(1 Pt 1):E61-E66. Montrose-Rafizadeh C, Wang Y, Janczewski AM, Henderson TE, Egan JM. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Mol Cell Endocrinol. 1997;130(1-2):109-117. Perfetti R, Henderson TE, Wang Y, Montrose-Rafizadeh C, Egan JM. Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix. Pancreas. 1996;13(1):47-54.
Kyle J. Hewitt--2004-2005, Colorado College, Colorado Springs. Mentor: Patrice Morin, Ph.D., Laboratory of Cellular and Molecular Biology.Hewitt KJ, Agarwal R, Morin PJ. The Claudin gene family: expression in normal and neoplastic tissues. BMC Cancer. 2006;6(1):186.
Jonathan Hovda--2001-2002, University of North Dakota. Mentor: Thad Rosenberger, Ph.D., Brain Physiology and Metabolism Section.Rosenberger TA, Hovda JT, Peters JM. Targeted disruption of peroxisomal proliferator-activated receptor beta d results in distinct gender differences in mouse brain phospholipid and esterified FA levels. Lipids. 2002;37(5):495-500. Rosenberger TA, Villacreses NE, Hovda JT, Bosetti F, Weerasinghe G, Wine RN, Harry GJ, Rapoport SI. Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. J Neurochem. 2004;88(5):1168-1178.
Mariana A. Jimenez--2003, MARC Program, San Jose State University, California. Mentors: Bryan Devan, Ph.D. and Donald Ingram, Ph.D., Laboratory of Experimental Gerontology.Devan BD, Sierra-Mercado D Jr, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol Biochem Behav. 2004;79(4):691-699. Devan BD, Bowker JL, Duffy KB, Bharati IS, Jimenez M, Sierra-Mercado D Jr, Nelson CM, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology (Berl). 2006;183(4):439-445.
Nikhil S. Joshi--2002, Johns Hopkins School of Public Health. Mentor: Patricia J. Gearhart, Ph.D., Laboratory of Molecular Gerontology.Martomo SA, Fu D, Yang WW, Joshi NS, Gearhart PJ. Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase. J Immunol. 2005;174(12):7787-7791.
Lisa Kebejian--2004-2005, Columbia University, New York. Mentors: Bronwen Martin, Ph.D. and Stuart Maudsley, Ph.D., Laboratory of Neurosciences.Martin B, Pearson M, Kebejian L, Golden E, Keselman A, Bender M, Carlson O, Egan J, Ladenheim B, Cadet JL, Becker KG, Wood W, Duffy K, Vinayakumar P, Maudsley S, Mattson MP. Sex-dependent metabolic, neuroendocrine and cognitive responses to dietary energy Rrestriction and excess. Endocrinology. 2007 June; [Epub ahead of print].
Yuri Kruman--2001, University of Pennsylvania, Philadelphia. Mentor: Mark Mattson, Ph.D., Laboratory of Neurosciences. Kruman II, Schwartz E, Kruman Y, Cutler RG, Zhu X, Greig NH, Mattson MP. Suppression of uracil-DNA glycosylase induces neuronal apoptosis. J Biol Chem. 2004;279(42):43952-43960. Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci. 2002;22(5):1752-1762. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci. 2000;20(18):6920-6926. Lee J, Bruce-Keller AJ, Kruman Y, Chan SL, Mattson MP. 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins. J Neurosci Res. 1999;57(1):48-61.
Helen Lee--2003, 2nd year medical student, Loma Linda University, California. Mentor: Thad Rosenberger, Ph.D., Brain Physiology and Metabolism Section. Lee H, Villacreses NE, Rapoport SI, Rosenberger TA. In vivo imaging detects a transient increase in brain arachidonic acid metabolism: a potential marker of neuroinflammation. J Neurochem. 2004;91(4):936-945.
Lucy X. Lu--2003, University of Virginia, Charlottesville, Virginia. Mentors: Donald Ingram, Ph.D. and Min Zhu, Ph.D., Laboratory of Experimental Gerontology.Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol. 2004;39(7):1049-1059.
Arpun Nagaraja--2003-2005, 2005 Graduate, Parkville High School, Baltimore, Maryland. Mentors: Ilya Goldberg, Ph.D. and Josiah Johnston, B.S., Laboratory of Genetics. Johnston J, Nagaraja A, Hochheiser H, Goldberg IG. A flexible framework for web interfaces to image databases: supporting user-defined ontologies and links to external databases. IEEE International Symposium on Biomedical Imaging. 2006.
George Negrete--2000-2001, MARC Program, San Jose State University, California. 2000-Mentors: Myriam Gorospe, Ph.D. and John Kusiak, Ph.D., Laboratory of Biological Chemistry. 2001-Mentor: Patricia J. Gearhart, Ph.D., Laboratory of Molecular Gerontology. Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ. Absence of DNA polymerase h reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med. 2004;199(7):917-924.
Laura A. Novack--2005, University of North Carolina-Chapel Hill. Mentor: Sebastin Fugmann, Ph.D., Laboratory of Cellular and Molecular Biology.Fugmann SD, Messier C, Novack LA, Cameron RA, Rast JP. An ancient evolutionary origin of the Rag1/2 gene locus. Proc Natl Acad Sci USA. 2006;103:3728-3733.
Christopher Quigley--1999-2000, Loyola College, Baltimore, Maryland. Mentor: Edward Spangler, Laboratory of Experimental Gerontology.Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA. 2004;101(52):18171-18176.
Demetrio Sierra-Mercado, Jr.--2003-2004, MARC Program, University of Texas at San Antonio. Mentors: Bryan Devan, Ph.D. and Donald Ingram, Ph.D., Laboratory of Experimental Gerontology.Devan BD, Sierra-Mercado D Jr, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol Biochem Behav. 2004;79(4):691-699. Devan BD, Bowker JL, Duffy KB, Bharati IS, Jimenez M, Sierra-Mercado D Jr, Nelson CM, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology (Berl). 2006;183(4):439-445. Devan BD, Pistell PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, Sierra-Mercado D, Spangler EL, Ingram DK. Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor N(omega)-nitro-L-arginine methyl ester. Eur J Pharmacol. 2007; [Epub ahead of print].
John R. Slevin--2002, Washington University, St. Louis, Missouri. Mentors: Dong Liu, Ph.D. and Mark Mattson, Ph.D., Laboratory of Neurosciences.Liu D, Slevin JR, Lu C, Chan SL, Hansson M, Elmer E, Mattson MP. Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death. J Neurochem. 2003;86(4):966-979. Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP. mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8(3):389-414.
Bonnie Sun--2003, University of Pennsylvania, Philadelphia. Mentors: Nicola Ho, Ph.D. and Clair Francomano, M.D., Laboratory of Genetics.Ho NC, Guarnieri M, Brant LJ, Park SS, Sun B, North M, Francomano CA, Carson BS. Living with achondroplasia: quality of life evaluation following cervico-medullary decompression. Am J Med Genet A. 2004;131A(2):163-167.
Michael S. Wade--2003, MARC Program, CUNY, Brooklyn College, New York. Mentors: Dennis Taub, Ph.D. and Vishwa Deep-Dixit, Ph.D., Laboratory of Immunology. Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem. 2007;282(23):17259-17271. Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, Dissanayake SK, Earley R, Indig FE, Nickoloff BJ, Taub DD, Kallioniemi OP, Meltzer P, Morin PJ, Weeraratna AT. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. Oncogene. 2007;26(26):3846-3856. Weeraratna AT, Kalehua A, Deleon I, Bertak D, Maher G, Wade MS, Lustig A, Becker KG, Wood W 3rd, Walker DG, Beach TG, Taub DD. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp Cell Res. 2007;313(3):450-461.
Juwaira Waheed--2001, University of Maryland Baltimore County. Mentor: Robert J. Brosh, Jr., Ph.D., Laboratory of Molecular Gerontology. Brosh RM Jr, Waheed J, Sommers JA. Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J Biol Chem. 2002;277(26):23236-23245.
Kevin Whittington--2001, Johns Hopkins University, Baltimore, Maryland. Mentor: Irving Wainer, Ph.D., Chief, Bioanalytical and Drug Discovery Section, Laboratory of Clinical Investigation.Moaddel R, Jozwiak K, Yamaguchi R, Cobello C, Whittington K, Sarkar TK, Basak S, Wainer IW. On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the a3b4- and a4b2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;813(1-2):235-240. Moaddel R, Jozwiak K, Whittington K, Wainer IW. Conformational mobility of immobilized a3b2, a3b4, a4b2, and a4b4 nicotinic acetylcholine receptors. Anal Chem. 2005;77(3):895-901.
Carmen R. Wilson--2003, MARC Program, Hampton University, Virginia. Mentors: Mark Cookson, Ph.D. and David Miller, Ph.D., Laboratory of Neurogenetics.Miller DW, Wilson CR, Kaleem MA, Blackinton J, Cookson MR. Identification of the epitope of a monoclonal antibody to DJ-1. Neurosci Lett. 2005;374(3):203-206.
Lisa R. Witkin--2003, Pennsylvania State University, State College, Pennsylvania. Mentors: Darrell Abernethy, M.D., Ph.D. and Donald Mager, Pharm.D., Ph.D., Laboratory of Clinical Investigation.Mager DE, Merritt MM, Kasturi J, Witkin LR, Urdiqui-Macdonald M, Sollers JJ 3rd, Evans MK, Zonderman AB, Abernethy DR, Thayer JF. Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability. Biomed Sci Instrum. 2004;40:337-342.
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Updated: Thursday October 11, 2007