Inclusion Criteria:

• Patient is eligible for autologous transplant
• Patient has failed previous conventional therapies for stem cell collection, or is not considered by the physician to have a reasonable chance of collecting enough cells for transplant
• Patient has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Patient has recovered from all acute toxic effects of prior chemotherapy
• Patient has white blood cell count greater than 2.5 x 10^9 cells/L
• Patient has absolute neutrophil count (ANC) greater than 1.5 x 10^9 cells/L
• Patient has platelet count greater than 85 x 10^9 cells/L
• Patient has serum creatinine less than or equal to 1.5 mg/dL
• Patient has creatinine clearance greater than 60 mL/min
• Patient has liver function tests less than 2x upper limit of normal
• Patient has left ventricle ejection fraction greater than 45%
• Patient has forced expiratory volume in 1 second (FEV1) greater than 60% of predicted or diffusing capacity of lung carbon monoxide (DLCO) and greater than or equal to 45% of predicted
• Patient has no active infection of hepatitis B or C
• Patient is negative for HIV
• Patient has signed informed consent
• Women of child bearing potential agree to use an approved form of contraception

Exclusion Criteria:

• Patients with leukemia (Note: Patients with multiple myeloma must be evaluated for plasma cells or blasts within 24 hours prior to the first dose of AMD3100)
• Patient has an existing condition which, in the view of the Investigator, renders the patient at high risk from treatment complications
• Patient has a residual acute medical condition resulting from prior chemotherapy
• Patient has brain metastases or carcinomatous meningitis
• Patient has an acute infection
• Patient has a fever (temperature greater than 38 degrees C/100.4 degrees F)
• Patient has hypercalcaemia greater than 1 mg/dL above the upper limit of normal
• Female patient has positive pregnancy test
• Female patient is lactating
• Patient is of child-bearing potential and is unwilling to use adequate birth control
• Patients with actual body weight exceeding 175% of their ideal body weight
• Patients who previously received experimental therapy within 4 weeks of enrolling in this protocol or who are currently enrolled in another experimental protocol
• Patients who experience a deterioration in health between the time of enrollment and transplant (such that they no longer meet entry criteria) may be removed from study at the discretion of the treating physician, principal Investigator, or Sponsor