|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||
| Sponsored by: |
University of Kansas |
|---|---|
| Information provided by: | University of Kansas |
| ClinicalTrials.gov Identifier: | NCT00291083 |
Purpose
To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.
| Condition |
|---|
|
Breast Cancer |
| Study Type: | Observational |
| Study Design: | Cohort, Prospective |
| Official Title: | Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women |
| Enrollment: | 229 |
| Study Start Date: | October 2005 |
| Study Completion Date: | June 2008 |
| Primary Completion Date: | June 2008 (Final data collection date for primary outcome measure) |
To examine nipple aspirate fluid analysis in lactating women for local concentration of estrogen, prolactin, glucocorticoids, insulin, parity, prior lactation and age. NAF secretors have been reported to have modest increase in breast cancer risk compared to non-secretors . Estrogen levels have been found to be markedly higher in NAF samples than in the serum collected from the same women. Estradiol and estrone concentrations in premenopausal women are 10x and 20x greater in NAF samples than in serum and 50x and 35x greater in post-menopausal women not on HRT. It has been suggested that the disparity between serum and NAF levels may be due to local estrogen production via aromatase and sulfatase.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Medical center
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Kansas | |
| University of Kansas Medical Center | |
| Kansas City, Kansas, United States, 66160 | |
| Principal Investigator: | Carol J Fabian, MD | University of Kansas |
More Information
| Responsible Party: | University of Kansas Medical Center ( Carol Fabian ) |
| Study ID Numbers: | 8427 |
| Study First Received: | February 10, 2006 |
| Last Updated: | September 15, 2008 |
| ClinicalTrials.gov Identifier: | NCT00291083 |
| Health Authority: | United States: Institutional Review Board |
|
NAF nipple aspirate fluid breast atypia high risk for breast cancer |
breast epithelial hyperplasia Ki-67 hormones plus chemoprevention chemoprevention |
|
Hyperplasia Skin Diseases Breast Neoplasms Menopause Breast Diseases |
|
Neoplasms Neoplasms by Site |
