Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
---|---|
Information provided by: | National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
ClinicalTrials.gov Identifier: | NCT00300638 |
The purpose of this study is to determine whether long-term chronic alcoholism is associated with changes in emotional functioning and brain structure and function.
Condition | Intervention |
---|---|
Alcoholism |
Procedure: Magnetic Resonance Imaging (MRI) Behavioral: Interviews, cognitive tests, and emotional measurements |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Placebo Control, Single Group Assignment, Efficacy Study |
Official Title: | Affective and Conative Changes in Alcoholism |
Estimated Enrollment: | 80 |
Study Start Date: | August 2001 |
Estimated Study Completion Date: | August 2010 |
Estimated Primary Completion Date: | August 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1- MRI and interviews: Active Comparator
In our research, we are trying to understand where in the brain these emotional behaviors take place, and whether or not the brain functions differently for alcoholic and nonalcoholic individuals. We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
|
Procedure: Magnetic Resonance Imaging (MRI)
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Behavioral: Interviews, cognitive tests, and emotional measurements
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
|
This research investigates brain structure and function in alcoholics compared to healthy nonalcoholic individuals. Alcoholics have shown impairments in cognitive processing of emotional signals. Some alcoholics are impaired in social skills, and many are unable to implement the strategies for interpersonal interactions that they recommend for themselves. For example, alcoholics have difficulty interpreting non-verbal emotional cues and recognizing facial expressions of emotion. When listening to sentences, alcoholics also have some difficulty judging emotional intonations and emotional content. In our research, we are trying to understand where in the brain these emotional behaviors take place, and whether or not the brain functions differently for alcoholic and nonalcoholic individuals. We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Ages Eligible for Study: | 18 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Kayle S. Sawyer, BS | 617-638-5317 | KSLAYS@BU.EDU |
Contact: Marlene O. Berman, PhD | 617-638-4803 | oscar@bu.edu |
United States, Massachusetts | |
VA Hospital and Massachusetts General Hospital | Recruiting |
Boston, Massachusetts, United States, 02130 | |
Contact: Kayle S. Sawyer, BS 857-638-5317 KSLAYS@BU.EDU | |
Contact: Diane Merritt, MA 857-638-5317 DMERRITT@BU.EDU | |
Principal Investigator: Marlene O. Berman, PhD |
Principal Investigator: | Marlene O. Berman, PhD | Boston University |
Responsible Party: | Boston University School of Medicine and Boston VA ( Marlene Oscar Berman, PhD ) |
Study ID Numbers: | NIAAABER007112, NIH Grant R01 AA007112 |
Study First Received: | March 7, 2006 |
Last Updated: | October 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00300638 |
Health Authority: | United States: Federal Government |
Alcoholism Emotion Cognition Brain scans |
Mental Disorders Alcoholism Substance-Related Disorders Disorders of Environmental Origin Alcohol-Related Disorders |