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Sponsors and Collaborators: |
Mayo Clinic National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00662233 |
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
PURPOSE: This clinical trial is studying how well combination chemotherapy works in treating patients with sarcoma.
Condition | Intervention |
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Ovarian Cancer Sarcoma |
Drug: cyclophosphamide Drug: doxorubicin hydrochloride Drug: etoposide Drug: ifosfamide Drug: vincristine sulfate Procedure: adjuvant therapy Procedure: brachytherapy Procedure: intraoperative radiation therapy Procedure: neoadjuvant therapy Procedure: radiation therapy Procedure: therapeutic conventional surgery |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | A Pilot Study for Soft Tissue Sarcoma |
Estimated Enrollment: | 120 |
Study Start Date: | October 1991 |
Estimated Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
OBJECTIVES:
OUTLINE: This is a multicenter study.
NOTE: *Patients undergoing radiotherapy do not receive doxorubicin hydrochloride in week 18 or week 24.
After completion of treatment, patients are followed periodically for at least 5 years.
Ages Eligible for Study: | up to 21 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Diagnosis of any of the following:
No evidence distant metastatic disease (i.e., lung, bone, bone marrow)
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Study ID Numbers: | CDR0000582271, MAYO-919110 |
Study First Received: | April 18, 2008 |
Last Updated: | August 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00662233 |
Health Authority: | United States: Federal Government |
alveolar childhood rhabdomyosarcoma previously treated childhood rhabdomyosarcoma previously untreated childhood rhabdomyosarcoma recurrent childhood rhabdomyosarcoma nonmetastatic childhood soft tissue sarcoma recurrent childhood soft tissue sarcoma |
childhood desmoplastic small round cell tumor ovarian sarcoma stage II uterine sarcoma stage III uterine sarcoma embryonal childhood rhabdomyosarcoma |
Gonadal Disorders Malignant mesenchymal tumor Urogenital Neoplasms Ovarian Diseases Cyclophosphamide Etoposide phosphate Soft tissue sarcomas Genital Diseases, Female Neoplasms, Connective and Soft Tissue Etoposide Desmoplastic small round cell tumor Endocrine Gland Neoplasms Rhabdomyosarcoma |
Ovarian cancer Ovarian Neoplasms Genital Neoplasms, Female Endocrine System Diseases Vincristine Recurrence Doxorubicin Ifosfamide Sarcoma Uterine sarcoma Endocrinopathy Isophosphamide mustard |
Neoplasms by Histologic Type Immunologic Factors Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Mitosis Modulators Physiological Effects of Drugs Antimitotic Agents Antibiotics, Antineoplastic Immunosuppressive Agents Pharmacologic Actions |
Adnexal Diseases Neoplasms Neoplasms by Site Therapeutic Uses Tubulin Modulators Myeloablative Agonists Antineoplastic Agents, Alkylating Antirheumatic Agents Antineoplastic Agents, Phytogenic Alkylating Agents |