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Sponsored by: |
Rutgers University |
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Information provided by: | Rutgers University |
ClinicalTrials.gov Identifier: | NCT00662168 |
This proposed pilot study is to conduct detailed interviews into the medical, environmental, and family histories The second phase of this study project is to and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) and stored for a second phase of this pilot. The purpose is to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.
Condition |
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Carcinoid Carcinoma |
Study Type: | Observational |
Study Design: | Case-Only, Retrospective |
Official Title: | An Investigation of Eight Reported Cases of Small Intestinal Carcinoid Carcinoma in Multiple Family Members |
Estimated Enrollment: | 8 |
Study Start Date: | January 2008 |
Estimated Study Completion Date: | November 2008 |
Estimated Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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observation
Individuals with a diagnosis of carcinoid carcinoma
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There have not been any studies published which specifically describe the medical, environmental, and genetic factors in carcinoid tumors cases that have carcinoid in family members. While rare, with an incidence of four per 100, 000, carcinoid represents the most frequent malignancy affecting the small intestine. Because nearly half (49%) of the cases of gastrointestinal carcinoid tumors have hepatic metastasis at diagnosis, identification of the risk factors associated with carcinoid has the potential to increase early diagnosis and cure. Carcinoid tumors are thought to occur spontaneously and not associated with an inherited genetic abnormality that would increase a family member's risk for developing carcinoid cancer. There is a known inherited genetic abnormality that is associated with bronchial carcinoid tumors but only less than 10%. Gastrointestinal carcinoid tumors are not thought to be associated with a inherited genetic abnormality. There have been several small studies that have examined gastrointestinal carcinoid in multiple family members. It remains uncertain if these cases of carcinoid in multiple family members are characteristic of a heritable or environmental etiology. Most carcinoid cancer is not inherited; however, less than 10% of neuroendocrine carcinoid cancer is thought to be due to a change (called a "mutation") in a gene inherited from a parent. There are several genes that are suspected to be associated with carcinoid cancer, two of interest in this study is the Multiple Endocrine Neoplasia Type1 (MEN1), and succinate dehydrogenase complex, subunit D (SDHD) genes.
Ages Eligible for Study: | 12 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Individuals with carcinoid cancer that report to have a family member also with carcinoid tumor
Inclusion Criteria:
Exclusion Criteria:
Contact: Nancy Gardner, PhD | 973-991-1302 | gardnern@rutgers.edu or nancymgardner@msn.com |
United States, New Jersey | |
Rutgers University College of Nursing | Recruiting |
Newark, New Jersey, United States, 07102 | |
Contact: Nancy Gardner, PhD 973-991-1302 gardnern@rutgers.edu | |
Principal Investigator: Nancy Gardner, PhD |
Principal Investigator: | Nancy Gardner, PhD | Rutgers University |
Responsible Party: | Rutgers University ( Nancy Gardner, PhD. Assistant Professor ) |
Study ID Numbers: | 08-151 |
Study First Received: | April 17, 2008 |
Last Updated: | April 17, 2008 |
ClinicalTrials.gov Identifier: | NCT00662168 |
Health Authority: | United States: Institutional Review Board |
carcinoid familial Collect and describe information about the medical and environmental factors associated with each cases of carcinoid carcinoma Develop a genogram representing the family cancer history of cases of Carcinoid. |
Carcinoid tumor Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neuroepithelioma Carcinoid Tumor |
Adenocarcinoma Neoplasms, Glandular and Epithelial Neuroendocrine Tumors Carcinoma |
Neoplasms Neoplasms by Histologic Type Neoplasms, Nerve Tissue |