In comparison to the general population, major mental illness is associated with higher rates of heart disease, stroke, and diabetes. These problems can result in a life span that can be up to 25 years shorter than in people without a major mental illness. There are noninvasive ways (procedures that don’t use needles or require surgery) to predict these outcomes in research. Unfortunately, however, these procedures have not been used much in psychiatric research, even though there is growing evidence that major mental disorders are associated with significant risk of heart disease, stroke and diabetes. The purpose of this study is to compare the risk for these disorders in people with schizophrenia with the risk for these disorders in other people without schizophrenia. We hypothesize that people with schizophrenia will have more artery blockage than age- and body mass index (BMI)-matched people without schizophrenia, and that these age- and BMI-matched individuals will have more blockage than lean, young healthy adults.

Participants will be asked to do the following:

1. A screening session in which participants will take part in a diagnostic interview that will take about 2-3 hours to complete and will address subjects' medical history.
2. An ultrasound test of participants' heart and blood vessels where an ultrasound machine will use sound waves to create images that allow the main blood vessels in the neck to be examined. Participants will be lying down for the procedure, and a colorless gel will be applied to the side of their neck where the handheld probe (called a transducer) will be placed. The transducer will then be gently moved over each side of the neck. This procedure will take approximately 30 minutes.
3. A magnetic resonance image (MRI) study where the amount of fat in subjects' liver will be measured. The MRI involves having the body painlessly scanned inside a tubular machine, while lying on a table for about 45 minutes.