Safety, Tolerability, Pharmacodynamic Effects and Preliminary Evidence for Efficacy of the Anti-Hypertension Vaccine CYT006-AngQb - Full Text View

Sponsored by:	Cytos Biotechnology AG
Information provided by:	Cytos Biotechnology AG
ClinicalTrials.gov Identifier:	NCT00500786

Purpose

This is a multi-center, randomized, placebo-controlled, time-lagged, parallel-group study in healthy and hypertensive subjects to evaluate safety and tolerability of the vaccine CYT006-AngQb. The trial is double-blind for active vs. placebo within each treatment arm, but open with respect to AngQb dose escalation.

In the first arm, 16 healthy normotensive volunteers are treated with a one dose regimen consisting of a single s.c. injection of 100µg of AngQb or placebo. Upon satisfying safety and tolerability profile, as judged by the independent safety monitoring board, arm two is enrolled.

In arm two 36 patients with mild to moderate hypertension receive three s.c. injections of 100µg CYT006-AngQb (24 patients) or placebo (12 patients). The second and third injections are given 4 and 12 weeks after the first injection, respectively. Upon satisfying safety and tolerability profile, as judged by the independent safety monitoring board, arm three is enrolled.

In arm three 36 patients with mild to moderate hypertension receive three s.c. injections of 300µg CYT006-AngQb (24 patients) or placebo (12 patients). The second and third injections are given 4 and 12 weeks after the first injection, respectively.

The primary objective of the trial is to evaluate safety / tolerability of 3 dose regimens of CYT006-AngQb in healthy volunteers and patients with mild to moderate essential hypertension. Secondary objectives include the assessment of pharmacodynamic effects and their dose-response (immunogenicity and biomarkers of the renin-angiotensin system), and the exploration of clinical efficacy (effects on systolic and diastolic blood pressure)

Condition	Intervention	Phase
Essential Hypertension	Biological: CYT006-AngQb	Phase I Phase II

MedlinePlus related topics: High Blood Pressure

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patients with untreated mild-to-moderate essential hypertension, clinically diagnosed according to the World Health Organization criteria (systolic blood pressure =140–179 mm Hg and/or diastolic blood pressure =90–109 mm Hg on 3 consecutive occasions; standardized after 5 minutes in sitting position)
Patients with newly diagnosed essential hypertension or previously treated patients from whom antihypertensive therapy can be safely withdrawn for the duration of the study.
18 to 65 years of age, males and non-reproductive females (surgically sterilized or post-menopausal)
Written informed consent
Patient is willing and able to comply with all trial requirements

Exclusion Criteria:

Secondary hypertension
Severe essential hypertension
Current pharmacological treatment that could affect blood pressure
Significant renal insufficiency [Serum creatinine > 159 µmol/L (> 1.8 mg/dl)]
History of cerebrovascular disease
Type 1 Diabetes or poorly controlled Type 2 Diabetes
Body mass index (BMI) >32
Total cholesterol > 6.9 mmol/L (> 266 mg/dl)
Triglycerides > 3.5 mmol/L ( > 174.3 mg/dl)
Autoimmune diseases or severe allergies
Patients with a history of HIV infection, AIDS, hepatitis B or C, or other immunosuppressive disorders
Current diagnosis or a history of malignancy
Drug or alcohol abuse within the past 2 years
Pregnancy or breastfeeding
Present history of mental diseases
Participation in any drug trial within three month of onset of current trial
Previous participation in a clinical trial with a Qb based vaccine (DerQb, NicQb, AllQb)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00500786

Sponsors and Collaborators

Cytos Biotechnology AG

Investigators

Principal Investigator:

Frank D Wagner, MD

Parexel International, Berlin, Germany

More Information

Sponsor's web page This link exits the ClinicalTrials.gov site

Publications indexed to this study:

Tissot AC, Maurer P, Nussberger J, Sabat R, Pfister T, Ignatenko S, Volk HD, Stocker H, Müller P, Jennings GT, Wagner F, Bachmann MF. Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study. Lancet. 2008 Mar 8;371(9615):821-7.

Study ID Numbers:	CYT006-AngQb 01
Study First Received:	July 12, 2007
Last Updated:	July 12, 2007
ClinicalTrials.gov Identifier:	NCT00500786
Health Authority:	Germany: Paul-Ehrlich-Institut

Study placed in the following topic categories:

Vascular Diseases
Essential hypertension
Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 14, 2009