The Olfactory Model System and Rett and Kallmann Syndromes: Sniffing Out Insights into Brain Development
Tuesday, September 12, 2000
8:30 a.m.-5:00 p.m.
Conte Building 49, Conference Room 1A and B
NIH Workshop sponsored by
the Office of Rare Diseases, NIDCD,
NIMH, NICHD, and NINDS.
The olfactory system represents a simple model of neuronal development that is amenable to molecular and genetic approaches. The accessibility of the olfactory system for biopsy provides an opportunity to use this system as a window for exploring primary molecular genetic defects at the level of the developing central nervous system. This workshop will focus on recent findings in Rett and Kallmann syndromes and will explore strategies to enhance the utility of the olfactory model in understanding CNS developmental disorders.
Conference Agenda
| 8:00 a.m. | Registration and coffee |
| 8:30 a.m. | Welcome
James Battey, Director, NIDCD |
Rett/Kallmann Syndromes and Olfactory Pathology
Chair, Gabriele Ronnett
|
| 8:45 a.m. | What the nose can tell us about CNS development; olfactory biopsies
James Schwob, Tufts University
|
| 9:05 a.m. | Rett syndrome: Clinical experience
Kathleen Hunter, International Rett Syndrome Association
|
| 9:20 a.m. | MECP2 mutations in the causation of Rett syndrome
Uta Francke, Stanford University
|
| 9:50 a.m. | Gene expression approaches to the study of Rett syndrome
Jonathan Pevsner, Johns Hopkins School of Medicine |
| 10:15 a.m. | Break |
| 10:35 a.m. | Kallmann syndrome and olfaction
James Schwob, Tufts University
|
| 10:55 a.m. | The origin and the ecstasy of GnRH cells in zebrafish
Kathleen Whitlock, Cornell University
|
| 11:20 a.m. | Characterization of Anosmin-1 defect in X-linked form of Kallmann syndrome
Nadia Soussi-Yanicostas, Institut Pasteur
|
| 11:50 a.m. | GnRH migration and the Netrin receptor
Gerald Schwarting, University of Massachusetts, Shriver Center |
| | Lunch |
| Molecular Mechanisms of Olfactory Development
Chair, Randall Reed
|
| 1:30 p.m. | Targeting olfaction
Peter Mombaerts, The Rockefeller University
|
| 2:00 p.m. | In-vivo optical imaging of olfactory bulb function
Leo Belluscio, Duke University
|
| 2:30 p.m. | Molecular dissection of olfactory development
Randall Reed, Johns Hopkins School of Medicine
|
| 3:00 p.m. | Break |
| 3:15 p.m. | Neurotrophic factors that influence olfactory neuronal development
Gabriele Ronnett, Johns Hopkins School of Medicine
|
| 3:45 p.m. | NELF: A novel gene that influences olfactory axon outgrowth and LHRH neuronal migration
Susan Wray, NINDS, NIH
|
| 4:15 p.m. | The role of Slit in the olfactory system
Yi Rao, Washington University
|
| 4:45 p.m. | Future Directions
Round table discussion--Development of diagnostic tools
|
| 6:30 p.m. | No Host Dinner--Bethesda |
Workshop Planning Committee
Rochelle Small (NIDCR); Chiiko Asanuma (NIMH);
Giovanna Spinella, Cheryl Kitt (NINDS); Mary Lou Oster-Granite (NICHD)
Open to the Public
Directions and Maps
For More Information, contact:
Rochelle K. Small, Ph.D.
Program Director, Craniofacial Anomalies and Injuries
NIDCR, NIH
Natcher Building, Room 4AN-24K
Bethesda, MD 20892
Phone: (301) 594-9898
Fax: (301) 480-8318
E-mail: rochelle.small@nih.gov
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