Alopecia Areata Registry and Immunogenetic Mechanisms

This study is currently recruiting participants.

Verified by University of Minnesota, April 2008

Sponsors and Collaborators:	Hordinsky, Maria K., MD M.D. Anderson Cancer Center Columbia University University of Colorado at Denver and Health Sciences Center University of California
Information provided by:	University of Minnesota
ClinicalTrials.gov Identifier:	NCT00177073

Purpose

The goals of this study are to understand the genetic control of autoimmunity in alopecia areata (AA), to better understand the complex biology of the cycling hair follicle, and to use this knowledge to devise safe and effective treatments for this common disease.

Condition	Intervention
Alopecia Areata	Behavioral: questionnaires

MedlinePlus related topics: Hair Diseases and Hair Loss

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Retrospective
Official Title:	Alopecia Areata Registry and Immunogenetic Mechanisms

Further study details as provided by University of Minnesota:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Serum, WBC.

Estimated Enrollment:	2000
Study Start Date:	September 2001
Estimated Study Completion Date:	November 2010

Intervention Details:

Completion of questionaires.

Detailed Description:

The purpose of this registry is to collect patient epidemiology data as well as to provide samples that can be used for understanding the pathogenesis of AA, especially related to its genetic basis as a complex trait. There are three ways one can assess which genes are important: association studies in unrelated individuals, identify by descent in sib-pairs, and linkage or transmission by descent in multiplex families.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients with alopecia areata. Controls without alopecia areata.

Criteria

Inclusion Criteria:

All patients with AA, children and adults, who have been diagnosed by a dermatologist, who is an expert in the field of alopecia. Subtypes that are allowable are alopecia universalis, alopecia totalis, patchy persistent alopecia or transient mild alopecia.
Family members, related by blood, of these patients (preferably sib-pairs plus parents and multiplex families).
Age matched controls from spouses or clinic patients

Exclusion Criteria:

A person under the age of 18 years not accompanied by parent or guardian.
A person who is unable to comprehend the informed consent and sign the consent form.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00177073

Contacts

Contact: Maria Hordinsky, MD

612-625-1493

hordi001@umn.edu

Locations

United States, Minnesota
University of Minnesota	Recruiting
Minneapolis, Minnesota, United States, 55455
Contact: Maria Hordinsky, MD 612-625-1493 hordi001@umn.edu
Principal Investigator: Maria Hordinsky, MD

Sponsors and Collaborators

Hordinsky, Maria K., MD

M.D. Anderson Cancer Center

Columbia University

University of Colorado at Denver and Health Sciences Center

University of California

Investigators

Principal Investigator:

Maria Hordinsky, MD

University of Minnesota

More Information

Responsible Party:	University of Minnesota ( Maria Hordinsky, MD )
Study ID Numbers:	0107M05422, NIH N01-AR-2249-05
Study First Received:	September 13, 2005
Last Updated:	April 25, 2008
ClinicalTrials.gov Identifier:	NCT00177073
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Pathological Conditions, Anatomical
Alopecia Areata
Alopecia areata
Skin Diseases
Alopecia

Additional relevant MeSH terms:

Hair Diseases
Hypotrichosis

ClinicalTrials.gov processed this record on January 16, 2009